SCHEMBL460509

SCHEMBL460509

c1ccc(-c2ccnnc2-c2ccccc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSNK1D P48730 2/20 0.42
MAPK11 Q15759 2/20 0.42
MAPK14 Q16539 2/20 0.42
GABRA1 P14867 1/20 0.41
GABRG2 P18507 1/20 0.41
GABRB3 P28472 1/20 0.41
GABRA5 P31644 1/20 0.41
GABRA3 P34903 1/20 0.41
ALOX15 P16050 1/20 0.39
PTGS1 P23219 1/20 0.39
PTGS2 P35354 1/20 0.39
NPC1 O15118 1/20 0.39
MAPK1 P28482 1/20 0.39
RAB9A P51151 1/20 0.39
CCNA2 P20248 1/20 0.39
CDK2 P24941 1/20 0.39
ADORA2A P29274 2/20 0.38
ADORA1 P30542 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
NOTUM Q6P988 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL28994883 0.98 CSNK1D (0.41) CSNK1DMAPK11MAPK14GABRA1GABRG2
SCHEMBL11204410 0.89 GABRA1 (0.39) CSNK1DMAPK11MAPK14GABRA1GABRG2
SCHEMBL5224988 0.84 ALDH1A1 (0.54) MAPK11MAPK14NPC1RAB9ACCNA2
SCHEMBL18766413 0.77 NPC1 (0.38) CSNK1DMAPK11MAPK14GABRA1GABRG2
SCHEMBL25274620 0.76 CYP2A6 (0.43) CSNK1DNPC1MAPK1RAB9ACDK2
SCHEMBL11775153 0.76 L3MBTL1 (0.40) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL8893835 0.76 MAPK1 (0.38) CSNK1DGABRA1GABRG2GABRB3GABRA5
SCHEMBL22588702 0.76 SMARCA2 (0.53) NPC1MAPK1RAB9AADORA2AADORA1
SCHEMBL8891228 0.76 BACE1 (0.44) NPC1MAPK1RAB9ANOTUMTDO2
SCHEMBL10765951 0.76 LMNA (0.42) ALOX15NPC1MAPK1RAB9AADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 775 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12517282-B2 Contact lenses containing light absorbing regions and methods for their preparation JOHNSON & JOHNSON VISION CARE, INC. (US) 2026-01-06 US claimed
EP-4453642-A1 CONTACT LENSES CONTAINING LIGHT ABSORBING REGIONS AND METHODS FOR THEIR PREPARATION Johnson & Johnson Vision Care, Inc. (US) 2024-10-30 EP claimed
US-20230296807-A1 CONTACT LENSES CONTAINING LIGHT ABSORBING REGIONS AND METHODS FOR THEIR PREPARATION JOHNSON & JOHNSON VISION CARE, INC. 2023-09-21 US claimed
WO-2023119021-A1 CONTACT LENSES CONTAINING LIGHT ABSORBING REGIONS AND METHODS FOR THEIR PREPARATION JOHNSON & JOHNSON VISION CARE, INC. (US) 2023-06-29 WO claimed
CN-112851912-B A3+ B2 type hyperbranched epoxy resin precursor, modified composition, preparation method and application thereof 中国科学院宁波材料技术与工程研究所 2023-04-07 CN claimed
CN-112851911-B Bio-based A2+ B3 type hyperbranched epoxy resin precursor, modified composition, preparation method and application thereof 中国科学院宁波材料技术与工程研究所 2023-02-28 CN claimed
CN-112831027-B Bio-based A3+ B2 type hyperbranched epoxy resin precursor, modified composition, preparation method and application thereof 中国科学院宁波材料技术与工程研究所 2023-02-24 CN claimed
CN-111574747-B Coordination crosslinking type polyimide aerogel and preparation method thereof 陕西科技大学 2023-02-17 CN claimed
US-11571400-B2 ACAT1 inhibitors for treating cancer CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE, CHINESE ACADEMY OF SCIENCES (CN) 2023-02-07 US claimed
CN-114797493-B Temperature-resistant composite separation membrane and preparation method thereof 西南石油大学 2023-01-31 CN claimed
US-5436399-A Polycarbonateurethane copolymers chain extended by a diol, diamine, hydrazine or water; protective coatings; molding materials; synthetic leather; light, acid (oleic) and alcohol resistance; nonhydrolyziang ASAHI KASEL KOGYO KABUSHIKI KAISHA (JP) 1995-07-25 US claimed
EP-0446555-B1 Polymeric diphenyldiamines GOODYEAR TIRE & RUBBER (US) 1994-09-21 EP claimed
EP-0614925-A1 THERMOPLASTIC POLYURETHANE DERIVED FROM POLYTETRAMETHYLENE CARBONATE DIOL Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1994-09-14 EP claimed
EP-0499898-A2 Polymeric diphenyldiamines THE GOODYEAR TIRE & RUBBER COMPANY (US) 1992-08-26 EP claimed
US-5075421-A Antiozonants, curing agent THE GOODYEAR TIRE & RUBBER COMPANY (US) 1991-12-24 US claimed
EP-0446555-A1 Polymeric diphenyldiamines THE GOODYEAR TIRE & RUBBER COMPANY (US) 1991-09-18 EP claimed
US-5049625-A Ozone resistant rubber THE GOODYEAR TIRE & RUBBER COMPANY (US) 1991-09-17 US claimed
US-4931453-A CARDIOVASCULAR, HYPOTENSIVE AGENTS FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) 1990-06-05 US claimed
US-4149851-A Concentrated aqueous dye compositions containing a low molecular weight amide FIDELITY UNION TRUST COMPANY, EXECUTIVE TRUSTEE UNDER SANDOZ TRUST (US) 1979-04-17 US claimed
US-4137219-A STABILIZERS BAYER AKTIENGESELLSCHAFT (DE) 1979-01-30 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11571400-B2 ACAT1 inhibitors for treating cancer ACAT2, ACAT1, CEPT1 CSNK1D 4758/4885MAPK11 3265/4885MAPK14 3595/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.