Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 11/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TLR4 | O00206 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TYMS | P04818 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.42 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | GART | P22102 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14417312 | 0.91 | DHFR (0.61) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL13529957 | 0.84 | DHFR (0.60) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL3330977 | 0.82 | NOS1 (0.50) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| SCHEMBL29677940 | 0.80 | DHFR (0.46) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL12867928 | 0.80 | DHFR (0.46) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL24344111 | 0.76 | DHFR (0.51) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL221621 | 0.76 | DHFR (0.71) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL29658170 | 0.76 | DHFR (0.71) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| Pteroic Acid SCHEMBL245982 | 0.75 | DHFR (0.67) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Hydrochloric Acid SCHEMBL1230259 | 0.75 | DHFR (0.70) | DHFRKDM4ETLR4MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660093-B1 | AMMONIUM SALTS OF ORNITHINE DERIVATIVES FOR TREATING INFLAMMATORY DISEASES | HANA BIOSCIENCES INC (US) | 2008-07-16 | — | — | EP | disclosed |
| US-20070219204-A1 | Pharmaceutically active ornitihine derivatives, ammonium salts thereof and methods of making same | DANA-FARBER CANCER INSTITUTE | 2007-09-20 | — | — | US | disclosed |
| EP-1660093-A1 | AMMONIUM SALTS OF ORNITHINE DERIVATIVES FOR TREATING INFLAMMATORY DISEASES | Hana Biosciences, Inc. (US) | 2006-05-31 | — | — | EP | disclosed |
| US-20060079531-A1 | Pharmaceutically active ornithine derivatives, ammonium salts thereof and methods of making same | DANA-FARBER CANCER INSTITUTE | 2006-04-13 | — | — | US | disclosed |
| EP-1638973-A1 | PHARMACEUTICALLY ACTIVE ORNITHINE DERIVATIVES, AMMONIUM SALTS THEREOF AND METHODS OF MAKING SAME | DANA-FARBER CANCER INSTITUTE (US) | 2006-03-29 | — | — | EP | disclosed |
| US-6989386-B2 | Pharmaceutically active ornithine derivatives, ammonium salts thereof and methods of making same | DANA-FARBER CANCER INSTITUTE (US) | 2006-01-24 | — | — | US | disclosed |
| WO-2005016350-A1 | AMMONIUM SALTS OF ORNITHINE DERIVATIVES FOR TREATING INFLAMMATORY DISEASES | HANA BIOSCIENCES, INC. (US) | 2005-02-24 | — | — | WO | disclosed |
| US-20050032807-A1 | Methods of treating inflammatory diseases with ammonium salts of ornitihine derivatives | HANA BIOSCIENCES, INC. | 2005-02-10 | — | — | US | disclosed |
| WO-2004094427-A1 | PHARMACEUTICALLY ACTIVE ORNITHINE DERIVATIVES, AMMONIUM SALTS THEREOF AND METHODS OF MAKING SAME | DANA-FARBER CANCER INSTITUTE (US) | 2004-11-04 | — | — | WO | disclosed |
| US-20040072837-A1 | Pharmaceutically active ornithine derivatives, ammonium salts thereof and methods of making same | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2004-04-15 | — | — | US | disclosed |
| WO-2001056385-A1 | METHODS AND COMPOSITIONS FOR ENHANCING FORMYLTETRAHYDROPTEROYLPOLYGLUTAMATE IN PLANTS | NONOMURA ARTHUR M (US) | 2001-08-09 | — | — | WO | disclosed |
| US-6121195-A | STIMULATING CARBON FIXATION AND INCREASING THE GROWTH OF PLANTS BY ENHANCING THE AVAILABILITY OF C1-TETRAHYDROFOLATE IN THE LEAVES OF A PLANT | NONOMURA ARTHUR M (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0813510-A4 | METHODS AND COMPOSITIONS FOR ENHANCING FORMYLTETRAHYDROPTEROYLPOLYGLUTAMATE IN PLANTS | NONOMURA ARTHUR M (US) | 2000-07-26 | — | — | EP | disclosed |
| US-5846908-A | Methods and compositions for enhancing plant growth with p-amino- or p-nitro-benzoic acids | NONOMURA ARTHUR M (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0813510-A1 | METHODS AND COMPOSITIONS FOR ENHANCING FORMYLTETRAHYDROPTEROYLPOLYGLUTAMATE IN PLANTS | NONOMURA, Arthur M. (US) | 1997-12-29 | — | — | EP | disclosed |
| WO-1996027572-A1 | METHODS AND COMPOSITIONS FOR ENHANCING FORMYLTETRAHYDROPTEROYLPOLYGLUTAMATE IN PLANTS | NONOMURA ARTHUR M (US) | 1996-09-12 | — | — | WO | disclosed |
| EP-0251455-A2 | Amine derivatives of folic acid analogs | CYTOGEN CORPORATION (US) | 1988-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072837-A1 | Pharmaceutically active ornithine derivatives, ammonium salts thereof and methods of making same | OTC, OAT, DOHH | DHFR 996/4885KDM4E 879/4885TLR4 4440/4885 |
| US-20050032807-A1 | Methods of treating inflammatory diseases with ammonium salts of ornitihine derivatives | ARG1, OTC, OAT | DHFR 2948/4885KDM4E 1181/4885TLR4 615/4885 |
| US-20060079531-A1 | Pharmaceutically active ornithine derivatives, ammonium salts thereof and methods of making same | OTC, OAT, ODC1 | DHFR 1445/4885KDM4E 719/4885TLR4 4149/4885 |
| US-20070219204-A1 | Pharmaceutically active ornitihine derivatives, ammonium salts thereof and methods of making same | OTC, OAT, ODC1 | DHFR 2885/4885KDM4E 1117/4885TLR4 3585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.