Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | STAMBP | O95630 | 1/20 | 0.38 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7044113 | 0.84 | ALDH1A1 (0.52) | ALDH1A1KDM4ELMNATSHRSMN1; SMN2 | |
| SCHEMBL4611362 | 0.78 | TP53 (0.52) | ALDH1A1KDM4ELMNASMN1; SMN2TP53 | |
| SCHEMBL6746555 | 0.78 | KDM4E (0.47) | NTRK1KCNK3ALDH1A1KDM4ELMNA | |
| SCHEMBL4610877 | 0.78 | KMT2A (0.51) | ALDH1A1KDM4ELMNASMN1; SMN2MAPT | |
| SCHEMBL4613206 | 0.76 | MEN1 (0.41) | PDE10AALDH1A1KDM4ELMNATSHR | |
| SCHEMBL4612617 | 0.75 | MEN1 (0.52) | ALDH1A1KDM4ETSHRTP53HTT | |
| SCHEMBL7047164 | 0.75 | CA2 (0.52) | ALDH1A1MAPTKMT2AALOX15 | |
| SCHEMBL7039562 | 0.73 | RORC (0.54) | ALDH1A1ALOX15 | |
| SCHEMBL7046082 | 0.72 | P2RX7 (0.44) | KDM4ESMN1; SMN2KMT2ANPC1RAB9A | |
| SCHEMBL7046652 | 0.72 | P2RX7 (0.47) | KDM4ESMN1; SMN2MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040235833-A1 | Indole derivatives useful for the treatment of diseases | PFIZER INC | 2004-11-25 | — | — | US | claimed |
| EP-1460064-A1 | Indole-2-carboxamide derivatives useful as beta-2 agonists | Pfizer Limited (GB) | 2004-09-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235833-A1 | Indole derivatives useful for the treatment of diseases | IDO1, IDO2, INMT | NTRK1 3368/4885PDE10A 2570/4885PSMD14 4148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.