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SCHEMBL46141

SCHEMBL46141

COC(=O)C1(N(C)C(=O)Cc2c(C)ccc(Cl)c2C)CCN(OC)CC1

nearest known ligand 0.34

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ OPRM1 P35372 9/20 0.34
▸ SIGMAR1 Q99720 4/20 0.33
▸ OPRK1 P41145 3/20 0.32
▸ OPRD1 P41143 2/20 0.32
▸ CACNA1C Q13936 1/20 0.32
▸ ALDH1A1 P00352 2/20 0.30
▸ GAA P10253 1/20 0.30
▸ MEN1 O00255 1/20 0.30
▸ TP53 P04637 1/20 0.30
▸ CYP1A2 P05177 1/20 0.30
▸ CYP3A4 P08684 1/20 0.30
▸ CYP2D6 P10635 1/20 0.30
▸ TSHR P16473 1/20 0.30
▸ CYP2C19 P33261 1/20 0.30
▸ MTOR P42345 1/20 0.30
▸ RAB9A P51151 1/20 0.30
▸ KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL46139 0.91 OPRM1 (0.36) OPRM1OPRK1OPRD1CACNA1C
SCHEMBL12071074 0.91 OPRM1 (0.33) OPRM1SIGMAR1OPRK1OPRD1CACNA1C
SCHEMBL12071743 0.88 P2RX7 (0.37) OPRM1SIGMAR1OPRK1OPRD1CACNA1C
SCHEMBL46060 0.86 OPRM1 (0.39) OPRM1SIGMAR1OPRK1OPRD1CACNA1C
SCHEMBL46140 0.85 TSHR (0.32) OPRM1SIGMAR1ALDH1A1MEN1TSHR
SCHEMBL46351 0.85 OPRM1 (0.34) OPRM1SIGMAR1OPRK1OPRD1CACNA1C
SCHEMBL12071748 0.84 P2RX7 (0.40) OPRM1OPRK1OPRD1CACNA1CALDH1A1
SCHEMBL46387 0.84 OPRM1 (0.34) OPRM1OPRK1OPRD1CACNA1C
SCHEMBL16471041 0.83 SIGMAR1 (0.39) OPRM1SIGMAR1OPRK1OPRD1CACNA1C
SCHEMBL46135 0.83 EPHX2 (0.35) OPRM1SIGMAR1OPRK1OPRD1CACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2575469-B1 PESTICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2018-03-14 — — EP disclosed
US-9771365-B2 Spiroheterocyclic N-oxypiperidines as pesticides SYNGENTA PARTICIPATIONS AG (CH) 2017-09-26 — — US disclosed
US-9771365-B2 Spiroheterocyclic N-oxypiperidines as pesticides SYNGENTA PARTICIPATIONS AG (CH) 2017-09-26 — — US disclosed
EP-2575472-B1 METHOD OF CONTROLLING NEONICOTINOID RESISTANT HEMIPTERA USING SPIROHETEROCYCLIC PYRROLIDINE DIONE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-07-19 — — EP disclosed
US-9485989-B2 Method of controlling neonicotinoid resistant hemiptera SYNGENTA PARTICIPATIONS AG (CH) 2016-11-08 — — US disclosed
US-9485989-B2 Method of controlling neonicotinoid resistant hemiptera SYNGENTA PARTICIPATIONS AG (CH) 2016-11-08 — — US disclosed
US-9462808-B2 Pesticidal compositions SYNGENTA PARTICIPANTS AG (CH) 2016-10-11 — — US disclosed
US-9462808-B2 Pesticidal compositions SYNGENTA PARTICIPANTS AG (CH) 2016-10-11 — — US disclosed
EP-2575449-B1 PESTICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2016-04-27 — — EP disclosed
US-20150259345-A1 SPIROHETEROCYCLIC N-OXYPIPERIDINES AS PESTICIDES SYNGENTA LIMITED (GB) 2015-09-17 — — US disclosed
US-20130225411-A1 PESTICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION LLC (US) 2013-08-29 — — US disclosed
US-20130225411-A1 PESTICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION LLC (US) 2013-08-29 — — US disclosed
US-20130150394-A1 PESTICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION LLC (US) 2013-06-13 — — US disclosed
WO-2011151249-A2 METHOD OF CONTROLLING NEONICOTINOID RESISTANT HEMIPTERA SYNGENTA PARTICIPATIONS AG (CH) 2011-12-08 — — WO disclosed
US-20110301031-A1 SPIROHETEROCYCLIC N-OXYPIPERIDINES AS PESTICIDES SYNGENTA CROP PROTECTION LLC (US) 2011-12-08 — — US disclosed
US-20110301031-A1 SPIROHETEROCYCLIC N-OXYPIPERIDINES AS PESTICIDES SYNGENTA CROP PROTECTION LLC (US) 2011-12-08 — — US disclosed
WO-2011151247-A2 PESTICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2011-12-08 — — WO disclosed
WO-2011151194-A1 1, 8 -DIAZASPIRO [4.5] DECANE- 2, 4 -DIONE DERIVATIVES USEFUL AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2011-12-08 — — WO disclosed
WO-2011151248-A1 PESTICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2011-12-08 — — WO disclosed
WO-2010066780-A1 SPIROHETEROCYCLIC N-OXYPIPERIDINES AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2010-06-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110301031-A1 SPIROHETEROCYCLIC N-OXYPIPERIDINES AS PESTICIDES DDT, THOP1, KCNH1 OPRM1 127/4885SIGMAR1 194/4885OPRK1 104/4885
US-20130150394-A1 PESTICIDAL COMPOSITIONS ACHE, DDT, GAP43 OPRM1 1458/4885SIGMAR1 2633/4885OPRK1 2760/4885
US-20130225411-A1 PESTICIDAL COMPOSITIONS DDT, CIP2A, CYP51A1 OPRM1 2238/4885SIGMAR1 2570/4885OPRK1 3645/4885
US-20150259345-A1 SPIROHETEROCYCLIC N-OXYPIPERIDINES AS PESTICIDES DDT, THOP1, KCNH1 OPRM1 144/4885SIGMAR1 131/4885OPRK1 142/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.