Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | MMP16 | P51512 | 1/20 | 0.45 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4618678 | 0.94 | HTR6 (0.58) | PKMHTR6POLBTSHRMAPK1 | |
| SCHEMBL8046997 | 0.84 | HTR6 (0.69) | PKMHTR6POLBTSHRMAPK1 | |
| SCHEMBL18969789 | 0.82 | TSHR (0.54) | PKMHTR6POLBTSHRMAPK1 | |
| SCHEMBL2900381 | 0.80 | PKM (0.83) | PKMHTR6POLBGAASMN1; SMN2 | |
| SCHEMBL5012595 | 0.78 | SMN1; SMN2 (0.59) | PKMHTR6POLBTSHRMAPK1 | |
| SCHEMBL407215 | 0.78 | L3MBTL1 (0.64) | MAPK1GAASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL29482636 | 0.78 | L3MBTL1 (0.64) | MAPK1GAASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL16797504 | 0.77 | MAPK1 (0.81) | HTR6POLBTSHRMAPK1GAA | |
| SCHEMBL18969788 | 0.77 | HTT (0.56) | PKMPOLBTSHRMAPK1GAA | |
| SCHEMBL17392336 | 0.77 | MEN1 (0.60) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |