Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.46 |
| ▸ | THRB known ✓ | P10828 | 3/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.41 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.41 |
| ▸ | TST | Q16762 | 2/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | DUSP5 | Q16690 | 2/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | PKLR | P30613 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29532439 | 1.00 | PTGS1 (0.46) | PTGS1PTPN1HSPD1HSPE1TST | |
| SCHEMBL11527280 | 0.91 | NR4A1 (0.46) | PTGS1PTPN1HSPD1HSPE1TST | |
| SCHEMBL112075 | 0.89 | PTGS1 (0.44) | PTGS1PTPN1HSPD1HSPE1TST | |
| SCHEMBL29714757 | 0.89 | PTGS1 (0.44) | PTGS1PTPN1HSPD1HSPE1TST | |
| SCHEMBL29406702 | 0.89 | PTGS1 (0.44) | PTGS1PTPN1HSPD1HSPE1TST | |
| SCHEMBL590947 | 0.89 | PTGS1 (0.44) | PTGS1PTPN1HSPD1HSPE1TST | |
| Water SCHEMBL31189085 | 0.87 | PTGS1 (0.43) | PTGS1PTPN1HSPD1HSPE1TST | |
| SCHEMBL687109 | 0.84 | PTPN1 (0.42) | PTGS1PTPN1HSPD1HSPE1TST | |
| SCHEMBL30660941 | 0.83 | MPL (0.42) | PTGS1PTPN1HSPD1HSPE1TST | |
| SCHEMBL30660940 | 0.83 | MPL (0.42) | PTGS1PTPN1HSPD1HSPE1TST |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327149-B1 | METHODS OF HIGH-THROUGHPUT SCREENING FOR INTERNALIZING ANTIBODIES | UNIV CALIFORNIA (US) | 2012-12-05 | — | — | EP | disclosed |
| WO-2002033044-A9 | METHODS OF HIGH-THROUGHPUT SCREENING FOR INTERNALIZING ANTIBODIES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-03-15 | — | — | WO | disclosed |
| EP-2341346-A2 | Methods of high-throughput screening for internalizing antibodies and metal-chelating liposomes | The Regents of the University of California (US) | 2011-07-06 | — | — | EP | disclosed |
| EP-1327149-A4 | METHODS OF HIGH-THROUGHPUT SCREENING FOR INTERNALIZING ANTIBODIES | UNIV CALIFORNIA (US) | 2007-03-07 | — | — | EP | disclosed |
| US-20060263801-A1 | Methods of high-throughput screening for internalizing antibodies | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2006-11-23 | — | — | US | disclosed |
| US-7045283-B2 | Methods of high-throughput screening for internalizing antibodies | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-05-16 | — | — | US | disclosed |
| EP-1327149-A2 | METHODS OF HIGH-THROUGHPUT SCREENING FOR INTERNALIZING ANTIBODIES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-07-16 | — | — | EP | disclosed |
| US-20020182643-A1 | Methods of high-throughput screening for internalizing antibodies | UNITED STATES GOVERNMENT, THE | 2002-12-05 | — | — | US | disclosed |
| WO-2002033044-A2 | METHODS OF HIGH-THROUGHPUT SCREENING FOR INTERNALIZING ANTIBODIES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-04-25 | — | — | WO | disclosed |