SCHEMBL4625449

SCHEMBL4625449

CC(NCCO)c1cc(N)ccc1O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.40
PDE10A Q9Y233 1/20 0.39
POLB P06746 1/20 0.37
PRKCI P41743 1/20 0.37
MEN1 O00255 4/20 0.36
KMT2A Q03164 4/20 0.36
HTT P42858 2/20 0.36
MAPT P10636 1/20 0.36
MAPK1 P28482 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
ACHE P22303 1/20 0.36
TSHR P16473 2/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CASP1 P29466 1/20 0.35
PDCD1LG2 Q9BQ51 3/20 0.34
CD274 Q9NZQ7 3/20 0.34
ALDH1A1 P00352 4/20 0.34
TDP1 Q9NUW8 2/20 0.34
HPGD P15428 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2978324 0.83 POLB (0.39) POLBMEN1KMT2AHTTMAPT
SCHEMBL27886146 0.82 CA1 (0.36) ALOX5PDE10APRKCIMEN1KMT2A
SCHEMBL5682803 0.78 PDE10A (0.45) ALOX5PDE10APRKCIMEN1KMT2A
SCHEMBL5681763 0.77 POLB (0.68) POLBMEN1KMT2AMAPTMAPK1
SCHEMBL4135919 0.76 POLB (0.62) POLBMEN1KMT2AHTTMAPK1
SCHEMBL3653564 0.74 CYP3A4 (0.43) MEN1KMT2AHTTNPSR1ALDH1A1
SCHEMBL2986678 0.73 TYR (0.45) POLBPDCD1LG2CD274
SCHEMBL8016400 0.73 ADRB2 (0.42) PDE10ACA1CA2
SCHEMBL5685477 0.73 CASR (0.51) POLBMEN1KMT2AALDH1A1TDP1
SCHEMBL2739345 0.73 PDE10A (0.52) ALOX5PDE10APRKCIMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250347050-A1 FIBER-TREATING AGENT KAO CORPORATION (JP) 2025-11-13 US disclosed
US-20250305210-A1 FIBER-TREATING AGENT KAO CORPORATION (JP) 2025-10-02 US disclosed
EP-4528023-A1 FIBER-TREATING AGENT Kao Corporation (JP) 2025-03-26 EP disclosed
EP-4528021-A1 FIBER-TREATING AGENT Kao Corporation (JP) 2025-03-26 EP disclosed
US-20240200261-A1 FIBER-TREATING AGENT KAO CORPORATION (JP) 2024-06-20 US disclosed
US-20240068156-A1 FIBER-TREATING AGENT KAO CORPORATION (JP) 2024-02-29 US disclosed
US-20240060234-A1 FIBER-TREATING AGENT KAO CORPORATION (JP) 2024-02-22 US disclosed
US-20240058249-A1 FIBER-TREATING AGENT KAO CORPORATION (JP) 2024-02-22 US disclosed
US-20240049824-A1 FIBER-TREATING AGENT KAO CORPORATION (JP) 2024-02-15 US disclosed
EP-4317576-A1 FIBER-TREATING AGENT Kao Corporation (JP) 2024-02-07 EP disclosed
US-6958080-B2 Compositions for dyeing keratinous fiber LION CORPORATION (JP) 2005-10-25 US disclosed
US-6949630-B2 Cationic reactive dyes CIBA SPECIALTY CHEMICALS CORPORATION (US) 2005-09-27 US disclosed
US-6838561-B2 Primary intermediates for oxidative coloration of hair THE PROCTER & GAMBLE COMPANY (US) 2005-01-04 US disclosed
EP-1359891-A4 PRIMARY INTERMEDIATES FOR OXIDATIVE COLORATION OF HAIR P & G CLAIROL INC (US) 2004-12-01 EP disclosed
CN-1487817-A Primary intermediates for oxidative dyeing of hair P&G 2004-04-07 CN disclosed
EP-1359891-A2 PRIMARY INTERMEDIATES FOR OXIDATIVE COLORATION OF HAIR P&G-Clairol, Inc. (US) 2003-11-12 EP disclosed
US-20030106166-A1 Compositions for dyeing keratinous fiber LION CORPORATION (JP) 2003-06-12 US disclosed
US-20020144358-A1 Primary intermediates for oxidative coloration of hair WELLA OPERATIONS US, LLC 2002-10-10 US disclosed
EP-1234569-A1 COMPOSITIONS FOR DYEING HORNY FIBERS Lion Corporation (JP) 2002-08-28 EP disclosed
WO-2002062308-A2 PRIMARY INTERMEDIATES FOR OXIDATIVE COLORATION OF HAIR P&G-CLAIROL, INC. (US) 2002-08-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030106166-A1 Compositions for dyeing keratinous fiber KRT18, LPO, CKMT1A; CKMT1B ALOX5 1614/4885PDE10A 3339/4885POLB 354/4885
US-20020144358-A1 Primary intermediates for oxidative coloration of hair COX5A, CYC1, MT-CO1 ALOX5 561/4885PDE10A 2217/4885POLB 261/4885
US-20240058249-A1 FIBER-TREATING AGENT H1-5, FAU, H1-3 ALOX5 2610/4885PDE10A 4113/4885POLB 92/4885
US-20240068156-A1 FIBER-TREATING AGENT H1-5, H1-3, H1-4 ALOX5 2468/4885PDE10A 4135/4885POLB 51/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.