Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NAAA | Q02083 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 4/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18342073 | 0.83 | NAAA (0.46) | MEN1KMT2ANAAAATMCTSK | |
| SCHEMBL5340682 | 0.81 | PPARA (0.52) | MEN1TSHRKMT2AATMCTSK | |
| SCHEMBL18342075 | 0.79 | NAAA (0.45) | MEN1TSHRKMT2ANAAAATM | |
| SCHEMBL5144290 | 0.78 | NAAA (0.43) | MEN1TSHRKMT2ANAAAPPARA | |
| SCHEMBL3504292 | 0.78 | NAAA (0.44) | TSHRKMT2ANAAASMN1; SMN2 | |
| SCHEMBL5145960 | 0.77 | NPC1 (0.45) | NAAAATM | |
| SCHEMBL3834968 | 0.77 | SIGMAR1 (0.46) | NAAAACECTSKCTSS | |
| SCHEMBL8982552 | 0.76 | NAAA (0.44) | NAAACTSKCTSS | |
| SCHEMBL873380 | 0.76 | ALDH1A1 (0.48) | MEN1KMT2ANAAASMN1; SMN2 | |
| SCHEMBL25054029 | 0.76 | CTSS (0.69) | ACECTSKCTSSPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922306-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | Astellas Pharma Inc. (JP) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007026920-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-03-08 | — | — | WO | disclosed |