Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1969523 | 0.87 | CACNA1G (0.40) | F2CETP | |
| SCHEMBL4499074 | 0.85 | LTB4R2 (0.45) | MEN1KMT2ALTB4R2CYP1A2CYP3A4 | |
| SCHEMBL10670515 | 0.82 | LTB4R2 (0.44) | MEN1KMT2ALTB4R2CYP1A2CYP3A4 | |
| SCHEMBL9525464 | 0.82 | ALDH1A1 (0.43) | KMT2ALTB4R2MAPTGAAHTT | |
| SCHEMBL30797543 | 0.82 | ALDH1A1 (0.43) | KMT2ALTB4R2MAPTGAAHTT | |
| SCHEMBL10401421 | 0.82 | MTNR1A (0.40) | KMT2AHDAC6HDAC1MAPTF2 | |
| SCHEMBL9738368 | 0.81 | LTB4R2 (0.44) | MEN1KMT2ALTB4R2CYP1A2CYP3A4 | |
| SCHEMBL4437768 | 0.81 | MEN1 (0.54) | MEN1KMT2ALTB4R2CYP1A2CYP3A4 | |
| SCHEMBL1624311 | 0.81 | SMN1; SMN2 (0.51) | MEN1KMT2ACYP3A4CYP2C19HDAC6 | |
| SCHEMBL440958 | 0.80 | RXFP1 (0.43) | LTB4R2CYP1A2CYP3A4CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888538-A1 | (3,4-DIHYDRO-QUINAZOLIN-2-YL)-(2-ARYLOXY-ETHYL)-AMINES HAVING AN ACTIVITY ON THE 5-HT RECEPTOR | F. Hoffmann-Roche AG (CH) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006117305-A1 | (3,4-DIHYDRO-QUINAZOLIN-2-YL)-(2-ARYLOXY-ETHYL)-AMINES HAVING AN ACTIVITY ON THE 5-HT RECEPTOR | F. HOFFMANN-LA ROCHE AG (CH) | 2006-11-09 | — | — | WO | disclosed |