Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 3/20 | 0.37 |
| ▸ | PPID | Q08752 | 2/20 | 0.37 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PPIB | P23284 | 1/20 | 0.36 |
| ▸ | PPIA | P62937 | 1/20 | 0.36 |
| ▸ | PPIG | Q13427 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5672733 | 0.87 | HDAC2 (0.41) | OPRD1KDM1ANPC1RORCRAB9A | |
| SCHEMBL4634933 | 0.83 | OPRD1 (0.40) | OPRD1OPRM1NPC1KMT2APPID | |
| SCHEMBL5671905 | 0.76 | CCR1 (0.52) | NPC1KMT2AMAPK1 | |
| SCHEMBL4635399 | 0.75 | KDM1A (0.41) | KDM1AOPRM1KMT2APOLBRORC | |
| SCHEMBL4634337 | 0.74 | OPRM1 (0.43) | OPRD1KDM1AOPRM1KMT2A | |
| SCHEMBL3176370 | 0.71 | LMNA (0.51) | KMT2APOLBLTA4HPPIDMAPK1 | |
| SCHEMBL4634991 | 0.71 | HSD11B1 (0.41) | KMT2APOLBMAPK1 | |
| SCHEMBL21388111 | 0.71 | KDM1A (0.40) | KDM1AKMT2APOLBRORCMAPK1 | |
| SCHEMBL4634641 | 0.71 | ALDH1A1 (0.41) | POLBRORC | |
| SCHEMBL5671953 | 0.71 | HDAC2 (0.41) | OPRD1KDM1ANPC1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928829-A1 | PIPERIDINE DERIVATIVES AS ANTAGONISTS OF THE CC CHEMOKINE RECEPTOR CCR1 AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | Schering Aktiengesellschaft (DE) | 2008-06-11 | — | — | EP | disclosed |
| WO-2006066948-A1 | PIPERIDINE DERIVATIVES AS ANTAGONISTS OF THE CC CHEMOKINE RECEPTOR CCR1 AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2006-06-29 | — | — | WO | disclosed |