Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NPFFR1 | Q9GZQ6 | 6/20 | 0.39 |
| ▸ | NPFFR2 | Q9Y5X5 | 6/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4634337 | 0.75 | OPRM1 (0.43) | KDM1AHSD11B1OPRK1KMT2AOPRM1 | |
| SCHEMBL4633737 | 0.75 | OPRD1 (0.39) | KDM1AKMT2AOPRM1RORCMAPK1 | |
| SCHEMBL4634957 | 0.74 | HSD11B1 (0.44) | KDM1AHSD11B1NPFFR1NPFFR2KMT2A | |
| SCHEMBL4634537 | 0.74 | CYP46A1 (0.50) | HSD11B1OPRK1OPRM1OPRL1 | |
| SCHEMBL4634991 | 0.72 | HSD11B1 (0.41) | HSD11B1KMT2AALDH1A1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL5810883 | 0.71 | HSD11B1 (0.43) | KDM1AHSD11B1ALDH1A1POLB | |
| SCHEMBL5807513 | 0.70 | HTT (0.41) | HSD11B1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL4635362 | 0.70 | HSD11B1 (0.40) | HSD11B1OPRK1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL27225337 | 0.70 | ALDH1A1 (0.34) | KMT2AALDH1A1SMN1; SMN2MEN1POLB | |
| SCHEMBL2798597 | 0.69 | ALDH1A1 (0.43) | HSD11B1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928829-A1 | PIPERIDINE DERIVATIVES AS ANTAGONISTS OF THE CC CHEMOKINE RECEPTOR CCR1 AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | Schering Aktiengesellschaft (DE) | 2008-06-11 | — | — | EP | disclosed |
| US-20060167044-A1 | Piperidine derivatives and their use as anti-inflammatory agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2006-07-27 | — | — | US | disclosed |
| WO-2006066948-A1 | PIPERIDINE DERIVATIVES AS ANTAGONISTS OF THE CC CHEMOKINE RECEPTOR CCR1 AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167044-A1 | Piperidine derivatives and their use as anti-inflammatory agents | CCR1, CCR2, CCR3 | KDM1A 3174/4885HSD11B1 2270/4885NPFFR1 260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.