Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5674689 | 0.83 | MEN1 (0.45) | KMT2AKDM1A | |
| SCHEMBL4634957 | 0.78 | HSD11B1 (0.44) | OPRL1HSD11B1KMT2AKDM1A | |
| SCHEMBL4634537 | 0.77 | CYP46A1 (0.50) | OPRM1OPRL1HSD11B1OPRD1OPRK1 | |
| SCHEMBL4634991 | 0.76 | HSD11B1 (0.41) | HSD11B1KMT2A | |
| Hydrochloric Acid SCHEMBL5810883 | 0.75 | HSD11B1 (0.43) | HSD11B1KDM1A | |
| SCHEMBL4635399 | 0.75 | KDM1A (0.41) | OPRM1OPRL1HSD11B1KMT2AOPRK1 | |
| SCHEMBL4633737 | 0.74 | OPRD1 (0.39) | OPRM1KMT2AOPRD1KDM1A | |
| SCHEMBL5807513 | 0.74 | HTT (0.41) | HSD11B1 | |
| SCHEMBL4634641 | 0.73 | ALDH1A1 (0.41) | — | |
| SCHEMBL2798597 | 0.73 | ALDH1A1 (0.43) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928829-A1 | PIPERIDINE DERIVATIVES AS ANTAGONISTS OF THE CC CHEMOKINE RECEPTOR CCR1 AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | Schering Aktiengesellschaft (DE) | 2008-06-11 | — | — | EP | disclosed |
| WO-2006066948-A1 | PIPERIDINE DERIVATIVES AS ANTAGONISTS OF THE CC CHEMOKINE RECEPTOR CCR1 AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2006-06-29 | — | — | WO | disclosed |