Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807513 | 0.87 | HTT (0.41) | HSD11B1DPP4CNR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL4634991 | 0.84 | HSD11B1 (0.41) | HSD11B1CNR2ALDH1A1SMN1; SMN2FAAH | |
| SCHEMBL5674700 | 0.82 | HDAC2 (0.46) | CNR2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5810883 | 0.78 | HSD11B1 (0.43) | HSD11B1ALDH1A1POLB | |
| SCHEMBL4634537 | 0.77 | CYP46A1 (0.50) | HSD11B1OPRD1OPRK1 | |
| SCHEMBL4634933 | 0.75 | OPRD1 (0.40) | ALDH1A1OPRD1MEN1KMT2A | |
| SCHEMBL4635001 | 0.73 | CCR1 (0.57) | SMN1; SMN2LMNAHTT | |
| SCHEMBL2798597 | 0.73 | ALDH1A1 (0.43) | HSD11B1ALDH1A1POLB | |
| SCHEMBL4634716 | 0.73 | HSD11B1 (0.41) | HSD11B1ALDH1A1FAAHPOLBKMT2A | |
| SCHEMBL4634337 | 0.71 | OPRM1 (0.43) | HSD11B1OPRD1OPRK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928829-A1 | PIPERIDINE DERIVATIVES AS ANTAGONISTS OF THE CC CHEMOKINE RECEPTOR CCR1 AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | Schering Aktiengesellschaft (DE) | 2008-06-11 | — | — | EP | disclosed |
| WO-2006066948-A1 | PIPERIDINE DERIVATIVES AS ANTAGONISTS OF THE CC CHEMOKINE RECEPTOR CCR1 AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2006-06-29 | — | — | WO | disclosed |