SCHEMBL4646853

SCHEMBL4646853

O=C(C=COc1ccccc1)Nc1cccc(-c2ccccc2)c1

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 3/20 0.55
HIF1A Q16665 2/20 0.52
POLB P06746 2/20 0.51
MMP1 P03956 1/20 0.51
MMP2 P08253 1/20 0.51
MMP9 P14780 1/20 0.51
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
LPAR1 Q92633 1/20 0.50
LPAR2 Q9HBW0 1/20 0.50
LTB4R Q15722 1/20 0.50
ADORA3 P0DMS8 1/20 0.49
KDM4E B2RXH2 1/20 0.48
ALDH1A1 P00352 1/20 0.48
MAPT P10636 1/20 0.48
CNR1 P21554 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4645874 0.86 ALDH1A1 (0.57) HIF1APOLBMMP1MMP2MMP9
SCHEMBL4646053 0.84 MMP1 (0.71) HIF1AMMP1MMP2MMP9MEN1
SCHEMBL4648540 0.84 MMP1 (0.64) HIF1AMMP1MMP2MMP9MEN1
SCHEMBL4648115 0.81 HIF1A (0.51) HIF1AMMP1MMP2MMP9MEN1
SCHEMBL4647915 0.79 SMN1; SMN2 (0.56) HIF1APOLBMMP1MMP2MMP9
SCHEMBL4647116 0.79 MMP1 (0.57) MMP1MMP2MMP9MEN1KMT2A
SCHEMBL4646819 0.79 MAPT (0.54) HIF1APOLBMEN1KMT2AKDM4E
SCHEMBL4646176 0.78 EGFR (0.62) HIF1AMMP1MMP2MMP9MEN1
SCHEMBL4647415 0.78 HIF1A (0.47) HIF1AMMP1MMP2MMP9MEN1
SCHEMBL4648657 0.77 EGFR (0.47) HIF1APOLBMMP1MMP2MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8410316-B2 Iminopropene compound and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-04-02 US disclosed
US-20110319437-A1 IMINOPROPENE COMPOUND AND USE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-12-29 US disclosed
EP-1957459-A2 IMINOPROPENE COMPOUND AND USE THEREOF Sumitomo Chemical Company, Limited (JP) 2008-08-20 EP disclosed
WO-2007063702-A2 IMINOPROPENE COMPOUND AND USE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-06-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110319437-A1 IMINOPROPENE COMPOUND AND USE THEREOF IMPA1, INPP5A, CTRL MGLL 767/4885HIF1A 4805/4885POLB 4173/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.