Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.45 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2310025 | 0.87 | LMNA (0.62) | TSHRLMNACYP1A2CYP2D6CHRM1 | |
| SCHEMBL5084136 | 0.83 | LMNA (0.55) | TSHRLMNACYP1A2CYP2D6CHRM1 | |
| SCHEMBL27965729 | 0.82 | LMNA (0.54) | TSHRLMNACYP1A2CYP2D6CHRM1 | |
| Methane SCHEMBL28935271 | 0.81 | LMNA (0.53) | TSHRLMNACYP1A2CYP2D6CHRM1 | |
| SCHEMBL29299737 | 0.81 | LMNA (0.53) | TSHRLMNACYP1A2CYP2D6CHRM1 | |
| SCHEMBL5613361 | 0.80 | MMP8 (0.49) | TSHRLMNASMN1; SMN2MMP8PIN1 | |
| SCHEMBL14497800 | 0.80 | LMNA (0.51) | LMNACHRM1ALDH1A1SMN1; SMN2MMP8 | |
| SCHEMBL12267961 | 0.79 | NR1H4 (0.47) | LMNASMN1; SMN2PIN1 | |
| SCHEMBL28147664 | 0.79 | NPSR1 (0.49) | — | |
| SCHEMBL280235 | 0.79 | ALDH1A1 (0.48) | TSHRLMNAALDH1A1SMN1; SMN2PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581467-B1 | LIGANDS FOR METALS AND IMPROVED METAL-CATALYZED PROCESSES BASED THEREON | MASSACHUSETTS INST TECHNOLOGY (US) | 2016-10-12 | — | — | EP | disclosed |
| EP-2583958-B1 | Ligands for metals and improved metal-catalyzed processes based thereon | MASSACHUSETTS INST TECHNOLOGY (US) | 2016-08-10 | — | — | EP | disclosed |
| EP-2583958-A1 | Ligands for metals and improved metal-catalyzed processes based thereon | Massachusetts Institute of Technology (MIT) (US) | 2013-04-24 | — | — | EP | disclosed |
| CN-100548948-C | Metal ligands and improved metal catalytic processes based thereon | MASSACHUSETTS INST TECHNOLOGY (US) | 2009-10-14 | — | — | CN | disclosed |
| EP-1581467-A4 | LIGANDS FOR METALS AND IMPROVED METAL-CATALYZED PROCESSES BASED THEREON | MASSACHUSETTS INST TECHNOLOGY (US) | 2008-08-13 | — | — | EP | disclosed |
| US-7223879-B2 | Ligands for metals and improved metal-catalyzed processes based thereon | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2007-05-29 | — | — | US | disclosed |
| EP-1581467-A2 | LIGANDS FOR METALS AND IMPROVED METAL-CATALYZED PROCESSES BASED THEREON | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2005-10-05 | — | — | EP | disclosed |
| US-20040171833-A1 | Ligands for metals and improved metal-catalyzed processes based thereon | NATIONAL SCIENCE FOUNDATION | 2004-09-02 | — | — | US | disclosed |
| WO-2004052939-A2 | LIGANDS FOR METALS AND IMPROVED METAL-CATALYZED PROCESSES BASED THEREON | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2004-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171833-A1 | Ligands for metals and improved metal-catalyzed processes based thereon | THEM6, SLC30A6, SOD1 | TSHR 3988/4885LMNA 4379/4885CYP1A2 713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.