SCHEMBL4653445

SCHEMBL4653445

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](OP(N)O)[C@H]1O

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADORA3 P0DMS8 4/20 0.71
▸ ADORA1 P30542 3/20 0.71
▸ SMN1; SMN2 Q16637 2/20 0.71
▸ DPP4 P27487 1/20 0.71
▸ MEN1 O00255 1/20 0.71
▸ SLC28A1 O00337 1/20 0.71
▸ MAP3K7 O43318 1/20 0.71
▸ SLC28A2 O43868 1/20 0.71
▸ GAPDH P04406 1/20 0.71
▸ MAPK1 P28482 1/20 0.71
▸ ADORA2A P29274 1/20 0.71
▸ ADORA2B P29275 1/20 0.71
▸ STAT6 P42226 1/20 0.71
▸ PI4KA P42356 1/20 0.71
▸ KMT2A Q03164 1/20 0.71
▸ PI4K2B Q8TCG2 1/20 0.71
▸ DOT1L Q8TEK3 1/20 0.71
▸ SLC29A1 Q99808 1/20 0.71
▸ PI4K2A Q9BTU6 1/20 0.71
▸ SLC28A3 Q9HAS3 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8616982 0.93 ADORA3 (0.72) ADORA3ADORA1SMN1; SMN2DPP4MEN1
SCHEMBL8179689 0.92 ADORA3 (0.71) ADORA3ADORA1SMN1; SMN2DPP4MEN1
SCHEMBL23754814 0.88 ADORA3 (0.59) ADORA3ADORA1SMN1; SMN2DPP4MEN1
SCHEMBL23414488 0.87 ADORA3 (0.77) ADORA3ADORA1SMN1; SMN2DPP4MEN1
SCHEMBL4658306 0.87 ADORA3 (0.77) ADORA3ADORA1SMN1; SMN2DPP4MEN1
SCHEMBL7555711 0.87 LMNA (0.57) ADORA3ADORA1ADORA2AADORA2BSLC29A1
SCHEMBL15755555 0.86 ADORA3 (0.75) ADORA3ADORA1SMN1; SMN2DPP4MEN1
SCHEMBL23547979 0.86 ADORA3 (0.75) ADORA3ADORA1SMN1; SMN2DPP4MEN1
SCHEMBL21418864 0.86 ADORA3 (0.75) ADORA3ADORA1SMN1; SMN2DPP4MEN1
SCHEMBL16359953 0.86 ADORA3 (0.75) ADORA3ADORA1SMN1; SMN2DPP4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260043027-A1 LINKER, COMPOUND INCLUDING LINKER, METHOD OF PREPARING COMPOUND, USE OF LINKER, AND METHOD OF DELIVERING OLIGONUCLEOTIDES THROUGH LINKER SYNERK BIOTECH LTD (HK) 2026-02-12 — — US disclosed
WO-2025133603-A1 LIQUID-PHASE PROCESS FOR PREPARING OLIGONUCLEOTIDES Exactmer Limited (GB) 2025-06-26 — — WO disclosed
WO-2025053766-A2 DINUCLEOTIDE MONOPHOSPHATE DERIVATIVE, THE NUCLEIC ACID DERIVATIVE CONTAINING IT, AND THE METHOD OF OBTAINING IT SIEĆ BADAWCZA ŁUKASIEWICZ PORT POLSKI OŚRODEK ROZWOJU TECHNOLOGII (PL) 2025-03-13 — — WO disclosed
EP-4103578-A1 NOVEL MRNA 5'-END CAP ANALOGS MODIFIED WITHIN PHOSPHATE RESIDUES, RNA MOLECULE INCORPORATING THE SAME, USES THEREOF AND METHOD OF SYNTHESIZING RNA MOLECULE OR PEPTIDE Uniwersytet Warszawski (PL) 2022-12-21 — — EP disclosed
WO-2021162566-A1 NOVEL MRNA 5'-END CAP ANALOGS MODIFIED WITHIN PHOSPHATE RESIDUES, RNA MOLECULE INCORPORATING THE SAME, USES THEREOF AND METHOD OF SYNTHESIZING RNA MOLECULE OR PEPTIDE UNIWERSYTET WARSZAWSKI (PL) 2021-08-19 — — WO disclosed
CN-107532162-A Compositions and methods for editing nucleic acids in cells using oligonucleotides 托德·M·伍尔夫 2018-01-02 — — CN disclosed
EP-1340766-B1 Optically active DNA probe having phosphonic diester linkage TOSOH CORP (JP) 2008-11-12 — — EP disclosed
US-20050074760-A1 Enzymatic nucleic acids containing 5'-and/or 3'-cap structures RIBOZYME PHARMACEUTICALS, INC. 2005-04-07 — — US disclosed
EP-0959077-B1 Optically active DNA probe having phosphonic diester linkage TOSOH CORP (JP) 2004-09-01 — — EP disclosed
EP-1340766-A1 Optically active DNA probe having phosphonic diester linkage Tosoh Corporation (JP) 2003-09-03 — — EP disclosed
US-6586238-B1 Modified ribozymes; useful for cleavage of RNA or single-stranded DNA; Resistance to exonuclease degradation RIBOZYME PHARMACEUTICALS, INC. 2003-07-01 — — US disclosed
EP-1108724-A2 Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules RIBOZYME PHARMACEUTICALS, INC. (US) 2001-06-20 — — EP disclosed
US-6211354-B1 SINGLE-STRANDED DNA PROBE HAVING CHIRAL LINKER, AN O,O-DINUCLEOTIDE-2-AMINOETHYLPHOSPHONIC ACID, ATTACHED IN THE MIDDLE AND JOINED TO A FLORESCENT INTERCALATIVE DYE; ONE-STEP HYBRIDIZATION; NO ISOLATION STEP TOSCH CORPORATION (JP) 2001-04-03 — — US disclosed
US-5998203-A PARTICULARLY USEFUL FOR ENZYMATIC CLEAVAGE OF RNA OR SINGLE-STRANDED DNA. RIBOZYME PHARMACEUTICALS, INC. (US) 1999-12-07 — — US disclosed
EP-0959077-A1 Optically active DNA probe having phosphonic diester linkage Tosoh Corporation (JP) 1999-11-24 — — EP disclosed
EP-0886641-A2 SYNTHESIS OF METHOXY NUCLEOSIDES AND ENZYMATIC NUCLEIC ACID MOLECULES RIBOZYME PHARMACEUTICALS, INC. (US) 1998-12-30 — — EP disclosed
WO-1997026270-A2 SYNTHESIS OF METHOXY NUCLEOSIDES AND ENZYMATIC NUCLEIC ACID MOLECULES RIBOZYME PHARMACEUTICALS, INC. (US) 1997-07-24 — — WO disclosed
US-4845205-A 2,N6 -disubstituted and 2,N6 -trisubstituted adenosine-3'-phosphoramidites INSTITUT PASTEUR (FR) 1989-07-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050074760-A1 Enzymatic nucleic acids containing 5'-and/or 3'-cap structures RNGTT, MTAP, RNASEL ADORA3 2216/4885ADORA1 3137/4885SMN1; SMN2 3195/4885
US-20260043027-A1 LINKER, COMPOUND INCLUDING LINKER, METHOD OF PREPARING COMPOUND, USE OF LINKER, AND METHOD OF DELIVERING OLIGONUCLEOTIDES THROUGH LINKER SSU72, NSUN2, RNMT ADORA3 1351/4885ADORA1 2232/4885SMN1; SMN2 230/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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