Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 4/20 | 0.35 |
| ▸ | CACNB4 | O00305 | 3/20 | 0.33 |
| ▸ | CACNA1A | O00555 | 3/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.33 |
| ▸ | CACNG3 | O60359 | 3/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.33 |
| ▸ | CACNB3 | P54284 | 3/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.33 |
| ▸ | CACNG7 | P62955 | 3/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.33 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.33 |
| ▸ | CACNG1 | Q06432 | 3/20 | 0.33 |
| ▸ | CACNB2 | Q08289 | 3/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.33 |
| ▸ | CACNA1E | Q15878 | 3/20 | 0.33 |
| ▸ | CACNA2D4 | Q7Z3S7 | 3/20 | 0.33 |
| ▸ | CACNA2D3 | Q8IZS8 | 3/20 | 0.33 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4563278 | 0.92 | PGR (0.39) | PGR | |
| SCHEMBL4564158 | 0.90 | HTR2B (0.36) | — | |
| SCHEMBL4564251 | 0.87 | DRD2 (0.36) | DRD2DRD3HTR2AHCRTR2 | |
| SCHEMBL4657250 | 0.87 | LMNA (0.38) | BRD4BRD2BRD3DRD2DRD3 | |
| SCHEMBL4627857 | 0.85 | ALDH1A1 (0.32) | HCRTR2 | |
| SCHEMBL4628825 | 0.83 | RARB (0.39) | BRD4BRD2BRD3HCRTR2 | |
| SCHEMBL4564105 | 0.83 | PDE4A (0.37) | BRD4BRD2BRD3PDK2HCRTR2 | |
| SCHEMBL4563452 | 0.83 | PTGS2 (0.39) | — | |
| SCHEMBL4629499 | 0.80 | HSP90AA1 (0.39) | DRD2DRD3HTR2A | |
| SCHEMBL4564085 | 0.80 | HSP90AA1 (0.39) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125825-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079139-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |