SCHEMBL4662537

SCHEMBL4662537

COC(=O)C(Cl)(Cl)CCCCCCCCCC(Br)c1ccc(Cl)cc1

nearest known ligand 0.37

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.37
POLB P06746 1/20 0.37
SLC6A3 Q01959 2/20 0.36
CYP26A1 O43174 1/20 0.36
CNR2 P34972 1/20 0.34
GAA P10253 1/20 0.34
UTS2R Q9UKP6 5/20 0.34
CYP1A2 P05177 1/20 0.34
CNR1 P21554 2/20 0.33
MEN1 O00255 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4659891 0.87 GAA (0.47) L3MBTL1POLBSLC6A3CYP26A1CNR2
SCHEMBL4659918 0.79 PPARA (0.38) POLBCNR2CNR1KMT2A
SCHEMBL4659864 0.78 HDAC3 (0.41) L3MBTL1GAACYP1A2CNR1MEN1
SCHEMBL4661240 0.78 HTR1A (0.39) L3MBTL1POLBGAACYP1A2CNR1
SCHEMBL4661128 0.77 HDAC3 (0.48) L3MBTL1POLBGAACYP1A2CNR1
SCHEMBL4659908 0.75 HDAC8 (0.45) L3MBTL1POLBMEN1KMT2A
SCHEMBL4661257 0.74 MMP12 (0.40) L3MBTL1POLBGAACYP1A2CNR1
SCHEMBL4659861 0.74 HDAC3 (0.38) L3MBTL1POLBGAACYP1A2CNR1
SCHEMBL4662610 0.73 MME (0.35) L3MBTL1POLBGAACYP1A2CNR1
SCHEMBL4661171 0.73 MME (0.37) L3MBTL1POLBGAACYP1A2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1627866-B1 CARBOXYLIC ACID COMPOUND AND MEDICINE CONTAINING THE SAME KOWA CO (JP) 2008-12-24 EP disclosed
US-7109242-B2 Carboxylic compound and medicine comprising the same KOWA COMPANY, LTD. (JP) 2006-09-19 US disclosed
EP-1627866-A1 CARBOXYLIC ACID COMPOUND AND MEDICINE CONTAINING THE SAME Kowa Company Ltd. (JP) 2006-02-22 EP disclosed
US-20050009909-A1 Carboxylic compound and medicine comprising the same KOWA COMPANY, LTD. (JP) 2005-01-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050009909-A1 Carboxylic compound and medicine comprising the same CPT1A, GPR119, PNLIP L3MBTL1 2080/4885POLB 4352/4885SLC6A3 3303/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.