Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 13/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 13/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 12/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 12/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 12/20 | 0.35 |
| ▸ | DRD2 | P14416 | 8/20 | 0.34 |
| ▸ | DRD4 | P21917 | 8/20 | 0.34 |
| ▸ | DRD3 | P35462 | 7/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.33 |
| ▸ | ARG1 | P05089 | 1/20 | 0.33 |
| ▸ | ARG2 | P78540 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4666493 | 0.93 | KDM1A (0.33) | GNAO1KDM1AARG1ARG2 | |
| SCHEMBL4375229 | 0.85 | KDM1A (0.38) | GNAO1KDM1ACHRM2CHRM1CHRM4 | |
| SCHEMBL4664113 | 0.83 | HRH3 (0.43) | GNAO1CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL4667708 | 0.83 | GNAO1 (0.40) | GNAO1CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL4666494 | 0.82 | ACHE (0.43) | GNAO1KDM1ACHRM2CHRM1CHRM4 | |
| SCHEMBL4666482 | 0.81 | HRH3 (0.46) | GNAO1CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL4664576 | 0.79 | ALDH1A1 (0.48) | GNAO1 | |
| SCHEMBL4665997 | 0.78 | KDM1A (0.38) | GNAO1KDM1A | |
| SCHEMBL4375233 | 0.78 | HRH3 (0.40) | GNAO1KDM1ACHRM2CHRM1CHRM4 | |
| SCHEMBL4382650 | 0.77 | KDM1A (0.35) | KDM1AARG1ARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312273-A1 | Quinoline Derivatives Having Vegf Inhibiting Activity | HENNEQUIN LAURENT FRANCOIS ANDRE | 2008-12-18 | — | — | US | disclosed |
| US-7371765-B2 | Quinoline derivatives having VEGF inhibiting activity | ASTRAZENECA AB (SE) | 2008-05-13 | — | — | US | disclosed |
| US-20060148819-A1 | Chemical compounds | HENNEQUIN LAURENT F A | 2006-07-06 | — | — | US | disclosed |
| US-6887874-B2 | Cinnoline compounds | ASTRAZENECA AB (SE) | 2005-05-03 | — | — | US | disclosed |
| US-20030212055-A1 | Cinnoline compounds | ASTRAZENECA AB (SE) | 2003-11-13 | — | — | US | disclosed |
| US-20030207878-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2003-11-06 | — | — | US | disclosed |
| US-20030199491-A1 | Quinoline derivatives having vegf inhibiting activity | ASTRAZENECA AB (SE) | 2003-10-23 | — | — | US | disclosed |
| EP-1313726-A1 | QUINOLINE DERIVATIVES HAVING VEGF INHIBITING ACTIVITY | AstraZeneca AB (SE) | 2003-05-28 | — | — | EP | disclosed |
| EP-1311500-A2 | INDOLE, AZAINDOLE AND INDAZOLE DERIVATIVES HAVING VEGF INHIBITING ACTIVITY | AstraZeneca AB (SE) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002016348-A1 | ANTIANGIOGENIC BICYCLIC DERIVATIVES | ASTRAZENECA AB (SE) | 2002-02-28 | — | — | WO | disclosed |
| WO-2002012226-A1 | QUINOLINE DERIVATIVES HAVING VEGF INHIBITING ACTIVITY | ASTRAZENECA AB (SE) | 2002-02-14 | — | — | WO | disclosed |
| WO-2002012227-A2 | INDOLE, AZAINDOLE AND INDAZOLE DERIVATIVES HAVING VEGF INHIBITING ACTIVITY | ASTRAZENECA AB (SE) | 2002-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312273-A1 | Quinoline Derivatives Having Vegf Inhibiting Activity | VEGFA, FLT1, FLT4 | GNAO1 1728/4885KDM1A 1956/4885CHRM2 1224/4885 |
| US-20030199491-A1 | Quinoline derivatives having vegf inhibiting activity | VEGFA, FLT1, FLT4 | GNAO1 187/4885KDM1A 2997/4885CHRM2 2653/4885 |
| US-20060148819-A1 | Chemical compounds | VEGFA, NOS3, FLT4 | GNAO1 1348/4885KDM1A 3574/4885CHRM2 170/4885 |
| US-20030207878-A1 | Chemical compounds | CYP3A7, HTR3C, CNR1 | GNAO1 41/4885KDM1A 2487/4885CHRM2 232/4885 |
| US-20030212055-A1 | Cinnoline compounds | VEGFA, PGF, CCR7 | GNAO1 388/4885KDM1A 1890/4885CHRM2 902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.