Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672126 | 0.84 | NPBWR1 (0.42) | SIGMAR1ROCK2GSK3AGSK3BLMNA | |
| SCHEMBL4670086 | 0.83 | ROCK2 (0.61) | ROCK2TSHRDHODH | |
| SCHEMBL4673671 | 0.82 | SIGMAR1 (0.52) | SIGMAR1ALDH1A1L3MBTL1 | |
| SCHEMBL4673554 | 0.77 | KMT2A (0.47) | ROCK2TSHRDHODHALDH1A1ADORA3 | |
| SCHEMBL4670427 | 0.77 | ADORA2B (0.41) | ROCK2DHODHALDH1A1LMNAADORA3 | |
| SCHEMBL4670482 | 0.77 | DHODH (0.36) | MAOBROCK2MAOATSHRDHODH | |
| Hydrochloric Acid SCHEMBL9384727 | 0.76 | ADORA2B (0.40) | ROCK2DHODHALDH1A1LMNAADORA3 | |
| SCHEMBL4670041 | 0.75 | ADRB2 (0.42) | DHODH | |
| Water SCHEMBL4672111 | 0.74 | ADRB2 (0.42) | DHODHALDH1A1 | |
| SCHEMBL4670626 | 0.74 | ADRB2 (0.40) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054881-B1 | NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS | BAYER CORP (US) | 2008-07-30 | — | — | EP | disclosed |
| US-6903218-B2 | Sulfonamide substituted chroman derivatives | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-06-07 | — | — | US | disclosed |