Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4673552 | 0.85 | MAPK1 (0.49) | KMT2AMEN1GAASMN1; SMN2NPC1 | |
| SCHEMBL4676105 | 0.83 | PKM (0.46) | KMT2AMEN1GAASMN1; SMN2NPC1 | |
| SCHEMBL4673358 | 0.77 | MAOB (0.46) | ROCK2DHODHTSHRALDH1A1ADORA3 | |
| SCHEMBL4670086 | 0.76 | ROCK2 (0.61) | SMN1; SMN2ROCK2DHODHCYP1A2CYP2C19 | |
| SCHEMBL4670427 | 0.76 | ADORA2B (0.41) | SMN1; SMN2ROCK2DHODHALDH1A1ADORA3 | |
| Hydrochloric Acid SCHEMBL9384727 | 0.75 | ADORA2B (0.40) | KMT2AMEN1GAASMN1; SMN2ROCK2 | |
| SCHEMBL4670482 | 0.70 | DHODH (0.36) | KMT2ANPC1RAB9AROCK2DHODH | |
| SCHEMBL4670471 | 0.69 | ADRB2 (0.39) | KMT2AMEN1ROCK2DHODHTSHR | |
| SCHEMBL4670426 | 0.69 | ADRB2 (0.38) | KMT2AMEN1ROCK2DHODHALDH1A1 | |
| SCHEMBL18432812 | 0.69 | ALDH1A1 (0.47) | SMN1; SMN2ROCK2TSHRALDH1A1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054881-B1 | NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS | BAYER CORP (US) | 2008-07-30 | — | — | EP | disclosed |