Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 9/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003858 | 0.88 | ALDH1A1 (0.58) | ALDH1A1GAAALOX15TSHRMAPK1 | |
| SCHEMBL2009408 | 0.86 | HSD11B1 (0.59) | ALDH1A1HSD11B1MEN1KMT2ATDP1 | |
| SCHEMBL2006926 | 0.85 | HSD11B1 (0.58) | ALDH1A1HSD11B1MEN1KMT2ATDP1 | |
| SCHEMBL2006592 | 0.83 | MEN1 (0.47) | ALDH1A1HSD11B1MEN1KMT2AGAA | |
| SCHEMBL2007289 | 0.83 | MEN1 (0.47) | ALDH1A1HSD11B1MEN1KMT2AGAA | |
| SCHEMBL4688564 | 0.79 | PKM (0.54) | ALDH1A1HSD11B1MEN1KMT2AGAA | |
| SCHEMBL3144170 | 0.78 | ALDH1A1 (0.43) | ALDH1A1HSD11B1GAAALOX15MAPT | |
| SCHEMBL13270639 | 0.77 | KMT2A (0.48) | ALDH1A1HSD11B1MEN1KMT2ATDP1 | |
| SCHEMBL2012534 | 0.77 | HSD11B1 (0.59) | ALDH1A1HSD11B1MEN1KMT2ATDP1 | |
| SCHEMBL3139507 | 0.77 | CHRM4 (0.47) | ALDH1A1HSD11B1MAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981504-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV Remynd (BE) | 2008-10-22 | — | — | EP | claimed |
| WO-2007090617-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV REMYND (BE) | 2007-08-16 | — | — | WO | claimed |