Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL662543 | 0.89 | ALDH1A1 (0.35) | RENCYP3A4ALDH1A1 | |
| SCHEMBL665101 | 0.89 | REN (0.36) | RENCYP3A4ALDH1A1 | |
| SCHEMBL13154804 | 0.77 | REN (0.35) | RENCYP3A4ALDH1A1 | |
| SCHEMBL91265 | 0.70 | REN (0.41) | RENCYP3A4ALDH1A1 | |
| SCHEMBL8037049 | 0.70 | SMN1; SMN2 (0.37) | RENCYP3A4ALDH1A1 | |
| SCHEMBL662621 | 0.69 | REN (0.35) | RENCYP3A4 | |
| SCHEMBL662620 | 0.69 | REN (0.35) | RENCYP3A4 | |
| SCHEMBL78902 | 0.66 | LMNA (0.41) | RENCYP3A4ALDH1A1 | |
| SCHEMBL15525263 | 0.65 | TDP1 (0.34) | ALDH1A1 | |
| SCHEMBL661523 | 0.63 | KDM4E (0.41) | RENALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981847-A1 | SECONDARY AMINES AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007088514-A1 | SECONDARY AMINES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-08-09 | — | — | WO | disclosed |