Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 4/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CCR5 | P51681 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CCL5 | P13501 | 4/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694094 | 0.79 | CHRNB2 (0.44) | HPGDSMN1; SMN2CCR5ALDH1A1CHRNB2 | |
| SCHEMBL4694116 | 0.78 | HCRTR2 (0.38) | CCR5CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL4690538 | 0.78 | CCL5 (0.36) | CCR5CCL5 | |
| SCHEMBL4694680 | 0.78 | ALK (0.34) | MEN1KMT2ACCR5CCL5CHRNB2 | |
| SCHEMBL4692781 | 0.77 | PKM (0.36) | MEN1HPGDKMT2ACCR5ALDH1A1 | |
| SCHEMBL4690761 | 0.76 | KDM4E (0.43) | MEN1HPGDKMT2ASMN1; SMN2CCR5 | |
| SCHEMBL4695377 | 0.76 | CCR5 (0.37) | CCR5TSHRHSD17B10CCL5CHRNB2 | |
| SCHEMBL4692820 | 0.75 | CCL5 (0.35) | CCR5ALDH1A1CCL5KDM4EHTT | |
| SCHEMBL4690459 | 0.75 | MEN1 (0.37) | MEN1KMT2ACCR5ALDH1A1CCL5 | |
| SCHEMBL4693281 | 0.75 | CHRNB2 (0.43) | MEN1KMT2ASMN1; SMN2CCR5TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |