Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 2/20 | 0.34 |
| ▸ | CCL5 | P13501 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694943 | 0.82 | NPC1 (0.34) | ALDH1A1MAPK1HTTCCR5CCL5 | |
| SCHEMBL4695010 | 0.78 | KMT2A (0.38) | POLBALDH1A1CCR5CCL5KMT2A | |
| SCHEMBL4690190 | 0.76 | POLB (0.49) | POLBALDH1A1CYP1A2MAPK1HTT | |
| SCHEMBL4692061 | 0.76 | CCR5 (0.37) | ALDH1A1CYP1A2CCR5CCL5 | |
| SCHEMBL4695866 | 0.74 | CCR5 (0.36) | ALDH1A1CCR5CCL5KMT2A | |
| SCHEMBL4694234 | 0.74 | ALDH1A1 (0.41) | ALDH1A1MAPK1HTTNPC1 | |
| SCHEMBL4696881 | 0.73 | CCL5 (0.38) | ALDH1A1CCR5CCL5 | |
| SCHEMBL4692848 | 0.73 | ALDH1A1 (0.40) | POLBALDH1A1CCR5CCL5KMT2A | |
| SCHEMBL4692781 | 0.72 | PKM (0.36) | ALDH1A1CYP1A2MAPK1CCR5CCL5 | |
| SCHEMBL4695377 | 0.71 | CCR5 (0.37) | CYP1A2CCR5CCL5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |