Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.33 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4691532 | 0.85 | CHRNB2 (0.44) | HCRTR1HCRTR2TNF | |
| SCHEMBL4695666 | 0.83 | SMN1; SMN2 (0.42) | GFERHCRTR1HCRTR2TNFHRH4 | |
| SCHEMBL4694340 | 0.83 | TNF (0.36) | CHRM2HCRTR1HCRTR2TNFKMT2A | |
| SCHEMBL4693800 | 0.82 | RAB9A (0.43) | HCRTR1HCRTR2TNFKMT2AMEN1 | |
| SCHEMBL4695972 | 0.82 | CHRNB2 (0.40) | GFERHCRTR1HCRTR2TNFKMT2A | |
| SCHEMBL4694328 | 0.82 | TNF (0.35) | CHRM2CHRM3HCRTR1HCRTR2TNF | |
| SCHEMBL4694334 | 0.81 | HCRTR1 (0.43) | HCRTR1HCRTR2TNF | |
| SCHEMBL3281863 | 0.81 | HCRTR1 (0.48) | HCRTR1HCRTR2KCNH2TNF | |
| SCHEMBL4690403 | 0.81 | HCRTR1 (0.39) | HCRTR1HCRTR2TNFHRH4 | |
| SCHEMBL4694248 | 0.81 | ALDH1A1 (0.39) | HCRTR1HCRTR2TNFKMT2AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |