Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 3/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693625 | 0.85 | HCRTR1 (0.37) | HCRTR1HCRTR2TNFALDH1A1HPGD | |
| SCHEMBL4691396 | 0.85 | HCRTR1 (0.39) | HCRTR1HCRTR2TNFCYP11B1CYP11B2 | |
| SCHEMBL4692886 | 0.84 | ALDH1A1 (0.42) | HCRTR1HCRTR2TNFALDH1A1HPGD | |
| SCHEMBL4695935 | 0.84 | HCRTR2 (0.47) | HCRTR1HCRTR2TNFALDH1A1HPGD | |
| SCHEMBL4691534 | 0.84 | GFER (0.43) | HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL4690680 | 0.83 | HCRTR1 (0.42) | HCRTR1HCRTR2TNFHRH4ALDH1A1 | |
| SCHEMBL4692692 | 0.83 | HCRTR1 (0.45) | HCRTR1HCRTR2TNFHRH4ALDH1A1 | |
| SCHEMBL4690738 | 0.83 | HCRTR1 (0.46) | HCRTR1HCRTR2TNFALDH1A1HPGD | |
| SCHEMBL4693718 | 0.83 | TSHR (0.38) | HCRTR1HCRTR2TNFHPGD | |
| SCHEMBL4694354 | 0.83 | P2RX7 (0.44) | HCRTR1HCRTR2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |