Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 19/20 | 0.50 |
| ▸ | PROKR1 | Q8TCW9 | 19/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692448 | 0.85 | EPHX2 (0.46) | HTT | |
| SCHEMBL4695296 | 0.84 | ALDH1A1 (0.48) | USP2LMNATSHRHTTSMN1; SMN2 | |
| SCHEMBL4694265 | 0.84 | HCRTR1 (0.38) | FPR2PROKR1USP2LMNATSHR | |
| SCHEMBL3283680 | 0.81 | MAPT (0.41) | USP2LMNAHTTSMN1; SMN2 | |
| SCHEMBL4693291 | 0.78 | ALDH1A1 (0.44) | HTT | |
| SCHEMBL4690881 | 0.78 | SMN1; SMN2 (0.40) | LMNASMN1; SMN2 | |
| SCHEMBL4695193 | 0.78 | TRPV4 (0.40) | — | |
| SCHEMBL3286926 | 0.77 | TNF (0.41) | — | |
| SCHEMBL4693914 | 0.76 | LMNA (0.34) | USP2LMNATSHRHTTSMN1; SMN2 | |
| SCHEMBL4695666 | 0.76 | SMN1; SMN2 (0.42) | PROKR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |