Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4691491 | 0.81 | FPR2 (0.50) | ALDH1A1 | |
| SCHEMBL4691441 | 0.80 | CCR5 (0.67) | TSHRLMNAALDH1A1CCR5MEN1 | |
| SCHEMBL4689791 | 0.80 | EPHX2 (0.49) | ALDH1A1CCR5MEN1KMT2A | |
| SCHEMBL4691597 | 0.80 | FPR2 (0.47) | ALDH1A1CCR5 | |
| SCHEMBL4692842 | 0.77 | GBA1 (0.43) | ALDH1A1CCR5KMT2AUSP2POLB | |
| SCHEMBL4696460 | 0.74 | CCR5 (0.51) | TSHRLMNAALDH1A1CCR5MEN1 | |
| SCHEMBL4691646 | 0.74 | LMNA (0.59) | TSHRLMNAALDH1A1HTTCCR5 | |
| SCHEMBL4694247 | 0.72 | DRD2 (0.36) | ALDH1A1CCR5MAPK1 | |
| SCHEMBL3282872 | 0.72 | DRD2 (0.36) | ALDH1A1CCR5MAPK1 | |
| SCHEMBL4691804 | 0.72 | CCR5 (0.47) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |