Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 12/20 | 0.47 |
| ▸ | PROKR1 | Q8TCW9 | 12/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 2/20 | 0.38 |
| ▸ | CCL5 | P13501 | 4/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4691491 | 0.89 | FPR2 (0.50) | FPR2PROKR1ALDH1A1 | |
| SCHEMBL4695050 | 0.80 | TSHR (0.53) | CCR5ALDH1A1 | |
| SCHEMBL4689791 | 0.79 | EPHX2 (0.49) | CCR5ALDH1A1 | |
| SCHEMBL4692842 | 0.76 | GBA1 (0.43) | GAACCR5ALDH1A1 | |
| SCHEMBL4691807 | 0.74 | CCR5 (0.46) | FPR2PROKR1CCR5 | |
| SCHEMBL3282848 | 0.72 | GRIN2B (0.51) | — | |
| SCHEMBL4694987 | 0.72 | GRIN2B (0.51) | — | |
| SCHEMBL3282872 | 0.72 | DRD2 (0.36) | CCL5CCR5ALDH1A1 | |
| SCHEMBL4694247 | 0.72 | DRD2 (0.36) | CCL5CCR5ALDH1A1 | |
| SCHEMBL15548819 | 0.71 | FPR2 (0.83) | FPR2PROKR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |