Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | ANPEP | P15144 | 1/20 | 0.53 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.50 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371526 | 0.83 | FOLH1 (0.70) | FOLH1CYP2D6CYP2C9HIF1AANPEP | |
| SCHEMBL70351 | 0.83 | FOLH1 (0.70) | FOLH1CYP2D6CYP2C9HIF1AANPEP | |
| SCHEMBL30791058 | 0.83 | FOLH1 (0.70) | FOLH1CYP2D6CYP2C9HIF1AANPEP | |
| SCHEMBL46611 | 0.82 | ALDH1A1 (0.46) | FOLH1CYP2D6CYP2C9HIF1AKMT2A | |
| SCHEMBL1777321 | 0.81 | FOLH1 (0.68) | FOLH1CYP2D6CYP2C9HIF1AANPEP | |
| SCHEMBL129182 | 0.81 | FOLH1 (0.68) | FOLH1CYP2D6CYP2C9HIF1AANPEP | |
| SCHEMBL10655399 | 0.79 | FOLH1 (0.66) | FOLH1CYP2D6CYP2C9HIF1AANPEP | |
| SCHEMBL1421808 | 0.79 | FOLH1 (0.66) | FOLH1CYP2D6CYP2C9HIF1AANPEP | |
| SCHEMBL40393 | 0.79 | FOLH1 (0.66) | FOLH1CYP2D6CYP2C9HIF1AANPEP | |
| SCHEMBL46935 | 0.79 | BCL2 (0.66) | FOLH1CYP2D6CYP2C9HIF1AANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051044-A2 | NOVEL FORMATS FOR ORGANIC COMPOUNDS FOR USE IN RNA INTERFERENCE | NOVARTIS AG (CH) | 2015-04-09 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |
| US-20100168114-A1 | INVERTEBRATE ACETYLCHOLINESTERASE INHIBITORS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2010-07-01 | — | — | US | disclosed |
| US-20080312091-A1 | INVERTEBRATE ACETYLCHOLINESTERASE INHIBITORS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2008-12-18 | — | — | US | disclosed |
| WO-2008035379-A2 | PROCESS FOR AND INTERMEDIATES OF LEUKOTRIENE ANTAGONISTS | APTUIT LAURUS PRIVATE LIMITED (IN) | 2008-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168114-A1 | INVERTEBRATE ACETYLCHOLINESTERASE INHIBITORS | ACHE, BCHE, CHAT | FOLH1 367/4885CYP2D6 399/4885CYP2C9 207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.