Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTO1 | P78417 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CFTR | P13569 | 2/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30609844 | 0.82 | KDM4E (0.37) | GSTO1ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL23662174 | 0.81 | PAX8 (0.40) | GSTO1ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL21505876 | 0.79 | LMNA (0.52) | ALDH1A1NPC1RAB9ALMNAMAPT | |
| SCHEMBL3647095 | 0.79 | KDM4E (0.42) | GSTO1ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL3654697 | 0.75 | TRPM8 (0.39) | GSTO1ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL2552251 | 0.71 | NFKB1 (0.33) | L3MBTL1KDM4ENFKB1NFKB2RELA | |
| SCHEMBL7040682 | 0.71 | GRM5 (0.37) | ALDH1A1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL2411773 | 0.71 | ALDH1A1 (0.41) | GSTO1ALDH1A1USP30KDM4ETDP1 | |
| SCHEMBL3857070 | 0.71 | KDM4E (0.41) | ALDH1A1NPC1RAB9ALMNAMAPT | |
| SCHEMBL16529805 | 0.70 | MLYCD (0.40) | ALDH1A1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871739-A1 | COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006110668-A1 | COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2006-10-19 | — | — | WO | disclosed |