Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 4/20 | 0.63 |
| ▸ | CES1 | P23141 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30670483 | 1.00 | CES2 (0.63) | CES2CES1LMNAMAPK1GAA | |
| SCHEMBL11354965 | 1.00 | CES2 (0.63) | CES2CES1LMNAMAPK1GAA | |
| SCHEMBL1671676 | 1.00 | CES2 (0.63) | CES2CES1LMNAMAPK1GAA | |
| SCHEMBL10563843 | 0.85 | CES2 (0.49) | CES2CES1LMNAMAPK1GAA | |
| Benzylic Acid SCHEMBL1670871 | 0.85 | CES2 (0.49) | CES2CES1LMNAMAPK1GAA | |
| SCHEMBL9103702 | 0.84 | CES2 (0.47) | CES2CES1LMNAMAPK1GAA | |
| SCHEMBL275598 | 0.84 | LMNA (0.64) | CES2CES1LMNAMAPK1KMT2A | |
| SCHEMBL23972274 | 0.83 | CES2 (0.66) | CES2CES1LMNAMAPK1GAA | |
| SCHEMBL31407017 | 0.83 | CES2 (0.66) | CES2CES1LMNAMAPK1GAA | |
| SCHEMBL31407025 | 0.83 | CES2 (0.66) | CES2CES1LMNAMAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113355367-B | Application of ketoacid reductase in synthesis of chiral aromatic 2-hydroxy acid | 浙江工业大学 | 2024-03-26 | — | — | CN | claimed |
| CN-114733578-B | Vulcanizing liquid and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-01-05 | — | — | CN | claimed |
| US-20220325035-A1 | POLYESTER, POLYESTERAMIDE, AND POLYAMIDE COMPOSITIONS | IYER ANANTH V (US) | 2022-10-13 | — | — | US | claimed |
| CN-114733578-A | Vulcanizing liquid and preparation method and application thereof | 中国石油化工股份有限公司 | 2022-07-12 | — | — | CN | claimed |
| CN-113355299-B | Ketoacid reductase, gene, engineering bacterium and application in synthesis of chiral aromatic 2-hydroxy acid | 浙江工业大学 | 2022-05-24 | — | — | CN | claimed |
| CN-113355299-A | Ketoacid reductase, gene, engineering bacterium and application in synthesis of chiral aromatic 2-hydroxy acid | 浙江工业大学 | 2021-09-07 | — | — | CN | claimed |
| CN-113355367-A | Application of ketoacid reductase in synthesis of chiral aromatic 2-hydroxy acid | 浙江工业大学 | 2021-09-07 | — | — | CN | claimed |
| CN-108410831-B | Ketoacid reductase, gene, engineering bacterium and application in synthesis of chiral aromatic 2-hydroxy acid | 浙江工业大学 | 2021-07-27 | — | — | CN | claimed |
| EP-2485678-A1 | COFERONS AND METHODS OF MAKING AND USING THEM | Cornell University (US) | 2012-08-15 | — | — | EP | claimed |
| WO-2011043817-A1 | COFERONS AND METHODS OF MAKING AND USING THEM | CORNELL UNIVERSITY (US) | 2011-04-14 | — | — | WO | claimed |
| CN-113355367-B | Application of ketoacid reductase in synthesis of chiral aromatic 2-hydroxy acid | 浙江工业大学 | 2024-03-26 | — | — | CN | disclosed |
| CN-114733578-B | Vulcanizing liquid and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-01-05 | — | — | CN | disclosed |
| US-20230159538-A1 | PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS | GLOBAL BLOOD THERAPEUTICS, INC. | 2023-05-25 | — | — | US | disclosed |
| US-20230151016-A1 | PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS | GLOBAL BLOOD THERAPEUTICS INC (US) | 2023-05-18 | — | — | US | disclosed |
| US-20230151016-A1 | PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS | GLOBAL BLOOD THERAPEUTICS INC (US) | 2023-05-18 | — | — | US | disclosed |
| EP-0007204-A1 | Phenethanolamines, their formulations, use and preparation | ELI LILLY AND COMPANY (US) | 1980-01-23 | — | — | EP | disclosed |
| EP-0006766-A1 | Phenethanolamines, their formulations, use and preparation | ELI LILLY AND COMPANY (US) | 1980-01-09 | — | — | EP | disclosed |
| US-4172196-A | CEPHALOSPORINS | BRISTOL-MYERS COMPANY (US) | 1979-10-23 | — | — | US | disclosed |
| US-4112228-A | BACTERICIDES | BRISTOL-MYERS COMPANY (US) | 1978-09-05 | — | — | US | disclosed |
| US-3985738-A | ANTIBACTERIAL AGENTS | BRISTOL-MYERS COMPANY (US) | 1976-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230151016-A1 | PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS | PDK1, PDK2, PKM | CES2 4622/4885CES1 3293/4885LMNA 853/4885 |
| US-20230159538-A1 | PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS | PDK1, PDK2, PKM | CES2 4622/4885CES1 3293/4885LMNA 853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.