Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.44 |
| ▸ | CTSB | P07858 | 9/20 | 0.44 |
| ▸ | CTSS | P25774 | 9/20 | 0.44 |
| ▸ | CTSL | P07711 | 8/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | HCK | P08631 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4756631 | 0.88 | RET (0.40) | RET | |
| SCHEMBL4703612 | 0.83 | CTSS (0.34) | CTSKCTSBCTSSCTSL | |
| SCHEMBL4701830 | 0.82 | CTSK (0.37) | CTSKCTSBCTSSCTSL | |
| SCHEMBL4703746 | 0.82 | OPRM1 (0.37) | CTSKCTSBCTSSCTSLCHEK1 | |
| SCHEMBL4704896 | 0.80 | CTSK (0.34) | CTSKCTSBCTSSCTSL | |
| SCHEMBL4704688 | 0.80 | CTSL (0.33) | CTSKCTSBCTSSCTSL | |
| SCHEMBL4699887 | 0.79 | CTSS (0.34) | CTSKCTSBCTSSCTSL | |
| SCHEMBL4703317 | 0.79 | HRH3 (0.35) | CTSKCTSBCTSSCTSL | |
| SCHEMBL4704824 | 0.79 | CTSK (0.36) | CTSKCTSBCTSSCTSL | |
| SCHEMBL4703639 | 0.79 | CTSK (0.36) | CTSKCTSBCTSSCTSLPRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-10-01 | — | — | EP | disclosed |