Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 12/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4714080 | 0.89 | MAPT (0.68) | PYGLALDH1A1KMT2AMAPTPPARG | |
| SCHEMBL16127883 | 0.80 | PPARG (0.67) | PYGLALDH1A1KMT2AMAPTPPARG | |
| SCHEMBL10920514 | 0.76 | PYGL (0.61) | PYGLALDH1A1KMT2AMAPTCYP1A2 | |
| SCHEMBL14707354 | 0.76 | ALDH1A1 (0.72) | PYGLALDH1A1KMT2AMAPTHPGD | |
| SCHEMBL10144149 | 0.76 | ALDH1A1 (0.69) | ALDH1A1KMT2AMAPTPPARGNR1H4 | |
| SCHEMBL11036755 | 0.76 | RAB9A (0.60) | PYGLKMT2AMAPTCYP1A2HPGD | |
| SCHEMBL8840342 | 0.76 | NPC1 (0.60) | PYGLALDH1A1KMT2ACYP1A2HPGD | |
| SCHEMBL304416 | 0.75 | POLB (0.69) | PYGLALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL31218737 | 0.75 | HTT (0.60) | PYGLALDH1A1KMT2AMAPTPPARG | |
| SCHEMBL1459456 | 0.75 | ALDH1A1 (0.71) | ALDH1A1KMT2AMAPTPPARGNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404650-B1 | CARBOXAMIDE-SUBSTITUTED PHENYLUREA DERIVATIVES AND METHOD FOR PRODUCTION THEREOF AS MEDICAMENTS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-02-13 | — | — | EP | disclosed |
| US-20050143456-A1 | Carboxamide-substituted phenylurea derivatives, process for their preparation and their use as medicaments | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-06-30 | — | — | US | disclosed |
| US-6812250-B2 | FOR THERAPY TYPE II DIABETES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-11-02 | — | — | US | disclosed |
| EP-1404650-A1 | CARBOXAMIDE-SUBSTITUTED PHENYLUREA DERIVATIVES AND METHOD FOR PRODUCTION THEREOF AS MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2004-04-07 | — | — | EP | disclosed |
| US-20030176497-A1 | Carboxamide-substituted phenylurea derivatives, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2003-09-18 | — | — | US | disclosed |
| WO-2002096864-A1 | CARBOXAMIDE-SUBSTITUTED PHENYLUREA DERIVATIVES AND METHOD FOR PRODUCTION THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143456-A1 | Carboxamide-substituted phenylurea derivatives, process for their preparation and their use as medicaments | GLS, MPC2, PC | PYGL 102/4885ALDH1A1 647/4885KMT2A 1810/4885 |
| US-20030176497-A1 | Carboxamide-substituted phenylurea derivatives, process for their preparation and their use as medicaments | GLS, PC, CPS1 | PYGL 123/4885ALDH1A1 384/4885KMT2A 2095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.