Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.38 |
| ▸ | STK17B | O94768 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703982 | 0.91 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3CHEK2MKNK1 | |
| SCHEMBL4700986 | 0.91 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3CHEK1CHEK2 | |
| SCHEMBL4704666 | 0.91 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3AOC3 | |
| SCHEMBL4705165 | 0.91 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3AOC3 | |
| SCHEMBL3972925 | 0.87 | MAPK1 (0.44) | RENMAPK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3973856 | 0.81 | L3MBTL1 (0.47) | RENL3MBTL1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3973369 | 0.81 | REN (0.43) | RENMAPK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3977361 | 0.80 | REN (0.47) | RENMAPK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3974286 | 0.80 | REN (0.43) | RENL3MBTL1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3973371 | 0.79 | L3MBTL1 (0.53) | RENSLC6A2SLC6A4SLC6A3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001867-A2 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007110340-A2 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-04 | — | — | WO | disclosed |