Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4716576 | 0.84 | ALDH1A1 (0.40) | POLB | |
| SCHEMBL4714260 | 0.82 | MEN1 (0.43) | EPHX2POLBL3MBTL1 | |
| SCHEMBL4713873 | 0.81 | HRH3 (0.38) | HRH3TDP1 | |
| SCHEMBL4713689 | 0.80 | SMN1; SMN2 (0.38) | CCR5 | |
| SCHEMBL31142583 | 0.77 | GPR119 (0.43) | GPR119 | |
| SCHEMBL4715512 | 0.76 | SLC6A4 (0.48) | CCR5HRH3TDP1L3MBTL1 | |
| SCHEMBL4713356 | 0.75 | ALDH1A1 (0.41) | CCR5HCRTR2 | |
| SCHEMBL2056115 | 0.75 | HTR2A (0.55) | CCR5CCR6KCNH2KDM2BGPR119 | |
| SCHEMBL3320631 | 0.75 | CCR5 (0.43) | CCR5HRH3CCR6KCNH2EPHX2 | |
| SCHEMBL4711851 | 0.73 | HTT (0.43) | HRH3POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933830-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007007057-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | VERNALIS (R & D) LIMITED (GB) | 2007-01-18 | — | — | WO | disclosed |