Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 3/20 | 0.48 |
| ▸ | IMPDH1 | P20839 | 3/20 | 0.48 |
| ▸ | MPL | P40238 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29541692 | 0.80 | IMPDH2 (0.49) | IMPDH2IMPDH1AAK1CYP11B2CYP11B1 | |
| SCHEMBL26915350 | 0.79 | KDM1A (0.41) | IMPDH2IMPDH1CYP11B2CYP11B1PDK2 | |
| SCHEMBL26464731 | 0.79 | IMPDH2 (0.63) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL2898349 | 0.77 | GAA (0.53) | IMPDH2IMPDH1AAK1CYP11B2CYP11B1 | |
| SCHEMBL29454983 | 0.77 | IMPDH2 (0.60) | IMPDH2IMPDH1AAK1CYP11B2CYP11B1 | |
| SCHEMBL23493611 | 0.77 | LMNA (0.53) | IMPDH2IMPDH1AAK1GPR119 | |
| SCHEMBL5780722 | 0.77 | IMPDH2 (0.60) | IMPDH2IMPDH1AAK1CYP11B2CYP11B1 | |
| SCHEMBL30177609 | 0.77 | IMPDH2 (0.50) | IMPDH2IMPDH1AAK1PDK2GPR119 | |
| SCHEMBL472465 | 0.74 | PTK2 (0.62) | IMPDH2IMPDH1CYP11B2CYP11B1PDK2 | |
| SCHEMBL22170261 | 0.73 | IMPDH2 (0.60) | IMPDH2IMPDH1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057941-B1 | NEW PHENYL-DIHYDROPYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2019-11-20 | — | — | EP | disclosed |
| US-9636339-B2 | Phenyl-dihydropyridine derivatives as aldosterone synthase inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2017-05-02 | — | — | US | disclosed |
| US-9636338-B2 | Phenyl-dihydropyridine derivatives as inhibitors of aldosterone synthase | HOFFMANN-LA ROCHE INC. (US) | 2017-05-02 | — | — | US | disclosed |
| EP-3057940-A1 | PHENYL-DIHYDROPYRIDINE DERIVATIVES AS INHIBITORS OF ALDOSTERONE SYNTHASE | F.HOFFMANN-LA ROCHE AG (CH) | 2016-08-24 | — | — | EP | disclosed |
| EP-3057941-A1 | NEW PHENYL-DIHYDROPYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2016-08-24 | — | — | EP | disclosed |
| US-20160229807-A1 | NEW PHENYL-DIHYDROPYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2016-08-11 | — | — | US | disclosed |
| US-20160221954-A1 | PHENYL-DIHYDROPYRIDINE DERIVATIVES AS INHIBITORS OF ALDOSTERONE SYNTHASE | HOFFMANN-LA ROCHE INC. (US) | 2016-08-04 | — | — | US | disclosed |
| WO-2015055602-A1 | PHENYL-DIHYDROPYRIDINE DERIVATIVES AS INHIBITORS OF ALDOSTERONE SYNTHASE | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-23 | — | — | WO | disclosed |
| WO-2015055604-A1 | NEW PHENYL-DIHYDROPYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-23 | — | — | WO | disclosed |
| EP-2412372-A1 | 2-Aminooxazole derivatives for use as TRPV1 antagonists for treating i.a. pain, inflammation, neurodegenerative diseases or gastrointestinal diseases | Abbott Laboratories (US) | 2012-02-01 | — | — | EP | disclosed |
| US-7998993-B2 | TRPV1 antagonists | ABBOTT LABORATORIES (US) | 2011-08-16 | — | — | US | disclosed |
| EP-2220059-B1 | 2-AMINOOXAZOLE DERIVATIVES AS TRPVL ANTAGONISTS USEFUL FOR TREATING PAIN | ABBOTT LAB (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2220059-A1 | 2-AMINOOXAZOLE DERIVATIVES AS TRPVL ANTAGONISTS USEFUL FOR TREATING PAIN | Abbott Laboratories (US) | 2010-08-25 | — | — | EP | disclosed |
| US-20090124666-A1 | TRPV1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2009-05-14 | — | — | US | disclosed |
| WO-2009055749-A1 | 2-AMINOOXAZOLE DERIVATIVES AS TRPVL ANTAGONISTS USEFUL FOR TREATING PAIN | ABBOTT LABORATORIES (US) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229807-A1 | NEW PHENYL-DIHYDROPYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | REN, CYP21A2, AGTR1 | IMPDH2 1157/4885IMPDH1 559/4885MPL 4585/4885 |
| US-20090124666-A1 | TRPV1 ANTAGONISTS | TRPV1, TRPV2, TRPV3 | IMPDH2 4461/4885IMPDH1 4147/4885MPL 4565/4885 |
| US-20160221954-A1 | PHENYL-DIHYDROPYRIDINE DERIVATIVES AS INHIBITORS OF ALDOSTERONE SYNTHASE | REN, CYP21A2, NR3C2 | IMPDH2 965/4885IMPDH1 441/4885MPL 4540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.