SCHEMBL472579

SCHEMBL472579

O=c1c2cc(Cl)ccc2sc2ccc(C(F)(F)F)cc12

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.61
MIF P14174 1/20 0.52
LMNA P02545 1/20 0.47
MAPT P10636 1/20 0.47
IDO1 P14902 4/20 0.47
TDO2 P48775 2/20 0.46
G6PD P11413 1/20 0.41
TLR9 Q9NR96 1/20 0.41
F10 P00742 1/20 0.39
AKR1B1 P15121 2/20 0.39
AKR1A1 P14550 1/20 0.39
BACE1 P56817 1/20 0.39
EPM2A O95278 1/20 0.38
PTPN2 P17706 1/20 0.38
PTPN1 P18031 1/20 0.38
PTPN22 Q9Y2R2 1/20 0.38
PIM1 P11309 1/20 0.38
PIM2 Q9P1W9 1/20 0.38
DDR1 Q08345 1/20 0.38
MCL1 Q07820 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29441239 1.00 KDM4E (0.61) KDM4EMIFLMNAMAPTIDO1
SCHEMBL16421246 0.90 G6PD (0.47) KDM4EMIFMAPTG6PDTLR9
SCHEMBL6070119 0.84 KDM4E (0.81) KDM4ELMNAMAPTIDO1PIM1
SCHEMBL30369262 0.82 KDM4E (0.58) KDM4ELMNAMAPTG6PDTLR9
SCHEMBL2810528 0.82 KDM4E (0.58) KDM4ELMNAMAPTG6PDTLR9
SCHEMBL16418954 0.81 KIF11 (0.57) KDM4EMIFMAPTG6PDTLR9
SCHEMBL11158985 0.78 G6PD (0.40) KDM4EMIFLMNAMAPTG6PD
SCHEMBL27952897 0.78 KDM4E (0.43) KDM4EMIFLMNAMAPTIDO1
SCHEMBL8438472 0.77 TTR (0.55) MIFMAPTPTPN1PIM1PIM2
SCHEMBL13276513 0.77 KDM4E (0.52) KDM4EMIFLMNAMAPTIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 298 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8367745-B2 Includes alkaline earth metal oxide as acidity neutralization stabilizer; quick setting, mechanical strength; repairing prosthesis GC CORPORATION (JP) 2013-02-05 US claimed
US-7678843-B2 Dental restorative material composition GC CORPORATION (JP) 2010-03-16 US claimed
EP-4029839-B1 GLASS POWDER AND CHEMICAL POLYMERIZATION INITIATOR G C DENTAL IND CORP (JP) 2026-05-06 EP disclosed
US-12600867-B2 Method of coating article, use for coating article, and polymerizable composition GC CORPORATION (JP) 2026-04-14 US disclosed
EP-3669854-B1 PHOTOPOLYMERIZABLE DENTAL COMPOSITION G C DENTAL IND CORP (JP) 2026-04-08 EP disclosed
US-12577340-B2 Storage stable two-component dual cure dental composition SOLVENTUM INTELLECTUAL PROPERTIES COMPANY (US) 2026-03-17 US disclosed
US-12569409-B2 Dental polymerizable composition GC CORPORATION (JP) 2026-03-10 US disclosed
US-12497476-B2 Antibacterial polymer particles, composition, and article GC CORPORATION (JP) 2025-12-16 US disclosed
EP-4652982-A1 DENTAL RESTORATION MATERIAL COMPOSITION GC R&D Corporation (JP) 2025-11-26 EP disclosed
US-12478561-B2 Dental composition and dental restorative kit GC CORPORATION (JP) 2025-11-25 US disclosed
US-12460021-B2 Glass powder and chemical polymerization initiator GC CORPORATION (JP) 2025-11-04 US disclosed
US-5364890-A (meth)acrylate and a carbodiimide GC CORPORATION (JP) 1994-11-15 US disclosed
US-5356951-A (Meth)acrylate monomer; composite filler; glass powder; fine particle filler; photoinitiator; surface smoothness; less shrinkage GC CORPORATION (JP) 1994-10-18 US disclosed
US-5290172-A Method for preparing a tooth surface for bonding GC CORPORATION (JP) 1994-03-01 US disclosed
US-5063255-A (Meth)acrylates G-C TOSHI KOGYO CORPORATION (JP) 1991-11-05 US disclosed
US-5043361-A Photopolymerizable blend of unsaturated compound, photoinitiator, reducing agent, filler and peroxide G-C DENTAL INDUSTRIAL CORPORATION (JP) 1991-08-27 US disclosed
US-4843110-A BLEND CONTAINING A THIOXANTHONE PHOTOINITIATOR G-C DENTAL INDUSTRIAL CORPORATION (JP) 1989-06-27 US disclosed
US-4820744-A TWO PARTS-UNSATURATED COMPOUND, INITIATOR, AND REDUCING AGENT SEPARATED FROM ORGANIC PEROXIDE AND FILLER G-C DENTAL INDUSTRIAL CORP. (JP) 1989-04-11 US disclosed
US-4544467-A PHOSPHOROUS-CONTAINING UNSATURATED MONOMER , SULFUR COMPOUND AND PHOTOINITIATOR; BONDING STRENGTH MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1985-10-01 US disclosed
EP-0132318-A1 Light-curable dentin and enamel adhesive MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1985-01-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12569409-B2 Dental polymerizable composition VCL, ACR, TPO KDM4E 2589/4885MIF 1994/4885LMNA 4252/4885
US-12600867-B2 Method of coating article, use for coating article, and polymerizable composition SARS1, SPIN1, ESPL1 KDM4E 1434/4885MIF 203/4885LMNA 3803/4885
US-12497476-B2 Antibacterial polymer particles, composition, and article PCNA, PARG, PUF60 KDM4E 3196/4885MIF 191/4885LMNA 3812/4885
US-12577340-B2 Storage stable two-component dual cure dental composition GPX4, SSRP1, H1-0 KDM4E 1053/4885MIF 4617/4885LMNA 1013/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.