SCHEMBL472943

SCHEMBL472943

Cc1c(F)c(F)c(COC(=O)C2C(C=O)C2(C)C)c(F)c1F

nearest known ligand 0.68

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.68
MEN1 O00255 1/20 0.68
KMT2A Q03164 1/20 0.68
LMNA P02545 2/20 0.42
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
ADRA2A P08913 1/20 0.35
CNR1 P21554 1/20 0.35
ATM Q13315 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
TSHR P16473 1/20 0.34
IMPDH2 P12268 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7918010 1.00 TDP1 (0.68) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL7105787 0.93 TDP1 (0.58) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL359304 0.89 TDP1 (0.55) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL2580946 0.89 TDP1 (0.55) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL2579133 0.89 TDP1 (0.55) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL13227251 0.88 TDP1 (0.64) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL7522431 0.88 TDP1 (0.67) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL1920262 0.88 TDP1 (0.67) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL1920258 0.88 TDP1 (0.67) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL1920260 0.88 TDP1 (0.67) TDP1MEN1KMT2ALMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2412702-B1 METHOD FOR PRODUCING CYCLOPROPANECARBOXYLIC ACID ESTER SUMITOMO CHEMICAL CO (JP) 2014-12-03 EP disclosed
US-8168816-B2 Method for producing purified formylcyclopropane compound and intermediate of such formylcyclopropane compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-05-01 US disclosed
US-20120029227-A1 METHOD FOR PRODUCING CYCLOPROPANECARBOXYLIC ACID ESTER SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-02 US disclosed
EP-2412702-A1 METHOD FOR PRODUCING CYCLOPROPANECARBOXYLIC ACID ESTER Sumitomo Chemical Company, Limited (JP) 2012-02-01 EP disclosed
EP-1609776-B1 PROCESS FOR PRODUCTION OF CARBONYL COMPOUNDS SUMITOMO CHEMICAL CO (JP) 2011-03-02 EP disclosed
US-20100305353-A1 METHOD FOR PRODUCING PURIFIED FORMYLCYCLOPROPANE COMPOUND AND INTERMEDIATE OF SUCH FORMYLCYCLOPROPANE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-12-02 US disclosed
US-7700799-B2 Method for producing (2-formyl-1-alkenyl) cyclopropane compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-04-20 US disclosed
US-20090137839-A1 METHOD FOR PRODUCING (2-FORMYL-1-ALKENYL) CYCLOPROPANE COMPOUND SUMITOMO CHEMICAL COMPANY, LTD. (JP) 2009-05-28 US disclosed
US-7498459-B2 Method for producing (1-alkenyl)cyclopropane compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-03-03 US disclosed
EP-1463706-B1 PROCESS FOR PRODUCTION OF 3,3-DIMETHYL-2-FORMYLCYCLOPROPANECARBOXYLIC ACID DERIVATIVES SUMITOMO CHEMICAL CO (JP) 2008-02-27 EP disclosed
WO-2003059861-A1 PROCESS FOR PRODUCTION OF 3,3-DIMETHYL-2-FORMYLCYCLOPROPANECARBOXYLIC ACID DERIVATIVES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-07-24 WO disclosed
EP-0963976-B1 Oxyimino-substituted cyclopropanecarboxylate pesticides SUMITOMO CHEMICAL CO (JP) 2003-02-19 EP disclosed
EP-0939073-B1 Ester of 2,2-dimethyl-cyclopropanecarboxylic acid and their use as pesticides SUMITOMO CHEMICAL CO (JP) 2002-12-04 EP disclosed
EP-1188735-A1 Process for producing carbonyl or hydroxy compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-03-20 EP disclosed
US-20020025906-A1 Process for producing carbonyl or hydroxy compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-02-28 US disclosed
EP-1120393-A1 A process for producing 3,3-dimethyl-2-formylcyclopropane-carboxylic acid ester SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-08-01 EP disclosed
US-6225495-B1 PESTICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-05-01 US disclosed
US-6034128-A PESTICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-03-07 US disclosed
EP-0963976-A1 Oxyimino-substituted cyclopropanecarboxylate pesticides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-12-15 EP disclosed
EP-0939073-A1 Ester of 2,2-dimethyl-cyclopropanecarboxylic acid and their use as pesticides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-09-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120029227-A1 METHOD FOR PRODUCING CYCLOPROPANECARBOXYLIC ACID ESTER PCCA, COASY, GRHPR TDP1 4158/4885MEN1 3565/4885KMT2A 3385/4885
US-20090137839-A1 METHOD FOR PRODUCING (2-FORMYL-1-ALKENYL) CYCLOPROPANE COMPOUND ACSL3, ACSL1, ARL1 TDP1 4458/4885MEN1 2164/4885KMT2A 2422/4885
US-20100305353-A1 METHOD FOR PRODUCING PURIFIED FORMYLCYCLOPROPANE COMPOUND AND INTERMEDIATE OF SUCH FORMYLCYCLOPROPANE COMPOUND FPR1, FPR2, DHPS TDP1 3608/4885MEN1 1957/4885KMT2A 2717/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.