Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 14/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 14/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731545 | 0.85 | ALDH1A1 (0.46) | HPGDSEGFRALDH1A1 | |
| SCHEMBL4780927 | 0.85 | ALDH1A1 (0.46) | HPGDSEGFRALDH1A1 | |
| SCHEMBL4728653 | 0.85 | HPGDS (0.54) | HPGDS | |
| SCHEMBL4730657 | 0.81 | MAPT (0.35) | MEN1KMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL4730336 | 0.81 | ALDH1A1 (0.36) | PDGFRBPDGFRAMEN1KMT2AKDM4E | |
| SCHEMBL5511161 | 0.79 | MGAM (0.49) | HPGDSKMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL5509233 | 0.76 | ABCG2 (0.52) | MEN1KMT2A | |
| SCHEMBL4726425 | 0.75 | MAOA (0.47) | CNR2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL4729401 | 0.75 | MAOA (0.47) | CNR2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL4729596 | 0.73 | PDGFRB (0.50) | PDGFRBPDGFRAPKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008035049-A1 | ADAMANTANYL-(CYCLOPROPYL)-KETONES AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-03-27 | — | — | WO | disclosed |