Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 11/20 | 0.61 |
| ▸ | CA1 | P00915 | 10/20 | 0.61 |
| ▸ | CA9 | Q16790 | 8/20 | 0.61 |
| ▸ | CA3 | P07451 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | DUSP5 | Q16690 | 2/20 | 0.36 |
| ▸ | DUSP6 | Q16828 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL9220931 | 0.74 | PTPN1 (0.50) | CA2CA1CA9CA12PTPN1 | |
| SCHEMBL1650498 | 0.73 | DUSP5 (0.55) | CA2CA1CA9CA12CA4 | |
| SCHEMBL4730286 | 0.73 | CA1 (0.61) | CA2CA1CA9CA3CA12 | |
| SCHEMBL10893549 | 0.69 | DUSP5 (0.45) | CA2CA1CA9CA12CA4 | |
| SCHEMBL18730197 | 0.69 | DUSP5 (0.45) | CA2CA1CA9CA12CA4 | |
| SCHEMBL216137 | 0.68 | PTPN1 (0.50) | CA2CA1CA9CA12PTPN1 | |
| Silver SCHEMBL216135 | 0.68 | PTPN1 (0.50) | CA2CA1CA9CA12PTPN1 | |
| SCHEMBL124132 | 0.68 | DUSP5 (0.54) | CA2CA1PTPN1DUSP5DUSP6 | |
| SCHEMBL3511719 | 0.68 | CA2 (0.64) | CA2CA1CA9CA3CA12 | |
| Potassium Ion SCHEMBL5359880 | 0.65 | CA1 (0.50) | CA2CA1CA9CA12LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008047129-A2 | LATENT FLUORESCENT PROBES | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2008-04-24 | — | — | WO | disclosed |