Sugi Predict

Sugi Predict / Compounds / SCHEMBL473140

SCHEMBL473140

SCHEMBL473140

CC(C)(C)CC[C@@H](O)C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ TET2 Q6N021 6/20 0.48
▸ KDM4A O75164 2/20 0.48
▸ KDM4C Q9H3R0 2/20 0.48
▸ KDM2A Q9Y2K7 2/20 0.48
▸ TET3 O43151 2/20 0.48
▸ GPR84 Q9NQS5 3/20 0.46
▸ FFAR1 O14842 1/20 0.46
▸ RIPK1 Q13546 2/20 0.42
▸ OR51E2 Q9H255 1/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ GRN P28799 2/20 0.38
▸ SORT1 Q99523 2/20 0.38
▸ ACACB O00763 1/20 0.38
▸ ACACA Q13085 1/20 0.38
▸ TP53 P04637 1/20 0.35
▸ TET1 Q8NFU7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1226074 1.00 TET2 (0.48) TET2KDM4AKDM4CKDM2ATET3
SCHEMBL2903998 1.00 TET2 (0.48) TET2KDM4AKDM4CKDM2ATET3
SCHEMBL25182596 0.88 GPR84 (0.56) TET2KDM4AKDM4CKDM2ATET3
SCHEMBL9742028 0.84 GPR84 (0.57) TET2KDM4AKDM4CKDM2ATET3
SCHEMBL8943253 0.83 TET2 (0.46) TET2KDM4AKDM4CKDM2ATET3
SCHEMBL8943261 0.83 TET2 (0.46) TET2KDM4AKDM4CKDM2ATET3
SCHEMBL1781574 0.80 RIPK1 (0.38) RIPK1GRNSORT1ACACBACACA
SCHEMBL30830420 0.79 TET2 (0.43) TET2KDM4AKDM4CKDM2ATET3
SCHEMBL8734216 0.79 RIPK1 (0.40) RIPK1GRNSORT1ACACBACACA
SCHEMBL25927118 0.78 RIPK1 (0.36) RIPK1GRNSORT1ACACBACACA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4676914-A1 MODULATORS OF SORTILIN ACTIVITY Vesper Bio Aps (DK) 2026-01-14 — — EP disclosed
US-20250268854-A1 2-AMINO-5,5-DIMETHYLHEXANOIC ACID DERIVATIVES AS SORTILIN MODULATORS FOR USE IN THE TREATMENT OF DISEASE OF THE CENTRAL NERVOUS SYSTEM VESPER BIO APS (DK) 2025-08-28 — — US disclosed
EP-4580750-A1 SORTILIN MODULATORS Vesper Bio Aps (DK) 2025-07-09 — — EP disclosed
CN-120077033-A Sortilin modulators 维斯珀生物应用有限公司 2025-05-30 — — CN disclosed
WO-2024184469-A1 MODULATORS OF SORTILIN ACTIVITY VESPER BIO APS (DK) 2024-09-12 — — WO disclosed
EP-4395776-A1 2-AMINO-5,5-DIMETHYLHEXANOIC ACID DERIVATIVES AS SORTILIN MODULATORS FOR USE IN THE TREATMENT OF DISEASE OF THE CENTRAL NERVOUS SYSTEM Insusense ApS (DK) 2024-07-10 — — EP disclosed
CN-118019533-A 2-Amino-5, 5-dimethylhexanoic acid derivatives as sortilin modulators for the treatment of central nervous system diseases 因苏森斯有限公司 2024-05-10 — — CN disclosed
WO-2024047227-A1 SORTILIN MODULATORS INSUSENSE ApS (DK) 2024-03-07 — — WO disclosed
WO-2023031440-A1 2-AMINO-5,5-DIMETHYLHEXANOIC ACID DERIVATIVES AS SORTILIN MODULATORS FOR USE IN THE TREATMENT OF DISEASE OF THE CENTRAL NERVOUS SYSTEM INSUSENSE ApS (DK) 2023-03-09 — — WO disclosed
US-20150038333-A1 PLANT PROTECTIVE COMPOSITION CONTAINING ALPHA-HYDROXY ACIDS HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENT -RUN FÜR GESUNDHEIT UND (DE) 2015-02-05 — — US disclosed
EP-1537078-B1 INDOLES HAVING ANTI-DIABETIC ACTIVITY MERCK SHARP & DOHME (US) 2010-04-14 — — EP disclosed
US-20090093416-A1 CASPASE INHIBITORS AND USES THEREOF VERTEX PHARMACEUTICALS INCORPORATED 2009-04-09 — — US disclosed
US-7345085-B2 Indoles having anti-diabetic activity MERCK & CO., INC. (US) 2008-03-18 — — US disclosed
US-20070161689-A1 Indoles having anti-diabetic activity MERCK SHARP & DOHME LLC 2007-07-12 — — US disclosed
US-7186746-B2 Indoles having anti-diabetic activity MERCK & CO., INC. (US) 2007-03-06 — — US disclosed
US-20050277685-A1 Indoles having anti-diabetic activity MERCK SHARP & DOHME LLC 2005-12-15 — — US disclosed
EP-1537078-A1 INDOLES HAVING ANTI-DIABETIC ACTIVITY Merck & Co., Inc. (US) 2005-06-08 — — EP disclosed
US-20040242494-A1 Caspase inhibitors and uses thereof VERTEX PHARMACEUTICALS INCORPORATED 2004-12-02 — — US disclosed
WO-2004020409-A1 INDOLES HAVING ANTI-DIABETIC ACTIVITY MERCK & CO., INC. (US) 2004-03-11 — — WO disclosed
WO-2004020408-A1 INDOLES HAVING ANTI-DIABETIC ACTIVITY MERCK & CO., INC. (US) 2004-03-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250268854-A1 2-AMINO-5,5-DIMETHYLHEXANOIC ACID DERIVATIVES AS SORTILIN MODULATORS FOR USE IN THE TREATMENT OF DISEASE OF THE CENTRAL NERVOUS SYSTEM SORT1, NMUR2, NMUR1 TET2 4634/4885KDM4A 2481/4885KDM4C 2804/4885
US-20040242494-A1 Caspase inhibitors and uses thereof CASP1, CASP5, CASP3 TET2 3971/4885KDM4A 1213/4885KDM4C 1553/4885
US-20150038333-A1 PLANT PROTECTIVE COMPOSITION CONTAINING ALPHA-HYDROXY ACIDS HAO1, HAAO, HAO2 TET2 3904/4885KDM4A 4287/4885KDM4C 4247/4885
US-20050277685-A1 Indoles having anti-diabetic activity GPR119, PPARA, PPARG TET2 3879/4885KDM4A 2342/4885KDM4C 2948/4885
US-20090093416-A1 CASPASE INHIBITORS AND USES THEREOF CASP1, CASP5, CASP3 TET2 3181/4885KDM4A 1001/4885KDM4C 1177/4885
US-20070161689-A1 Indoles having anti-diabetic activity GPR119, PPARA, PPARG TET2 3879/4885KDM4A 2342/4885KDM4C 2948/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.