Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | CNR1 | P21554 | 3/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738668 | 0.81 | CNR2 (0.40) | CNR2CNR1CFTRMAPTCYP3A4 | |
| SCHEMBL8190064 | 0.81 | CYP3A4 (0.42) | CNR2CNR1MAPTCYP3A4GPBAR1 | |
| SCHEMBL4739106 | 0.79 | NPC1 (0.41) | CNR2CNR1MAPTCYP3A4SMN1; SMN2 | |
| SCHEMBL3818747 | 0.78 | CNR2 (0.47) | CNR2CNR1MAPTCYP3A4SMN1; SMN2 | |
| SCHEMBL4735258 | 0.78 | ALDH1A1 (0.52) | KDM4ECNR2MAPTCYP3A4SMN1; SMN2 | |
| SCHEMBL8184199 | 0.77 | MAPK14 (0.44) | CNR2CNR1MAPTCYP3A4TP53 | |
| SCHEMBL4736786 | 0.77 | OPRM1 (0.41) | CNR2CNR1CYP3A4GPBAR1 | |
| SCHEMBL3824123 | 0.76 | CNR1 (0.41) | KDM4ECNR2CNR1MAPTCYP3A4 | |
| SCHEMBL4733672 | 0.76 | ALDH1A1 (0.44) | CNR2CNR1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4734930 | 0.73 | ALDH1A1 (0.45) | CNR2CNR1MAPTCYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |