Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.30 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737146 | 0.91 | TDP1 (0.36) | ADAM17TDP1MAOBPTPN1 | |
| SCHEMBL4733752 | 0.88 | ADAM17 (0.32) | ADAM17MMP8MMP14 | |
| SCHEMBL4735347 | 0.87 | ADAM17 (0.30) | ADAM17 | |
| SCHEMBL4734993 | 0.78 | CA2 (0.33) | ADAM17 | |
| SCHEMBL4738186 | 0.76 | CA12 (0.31) | MMP14 | |
| SCHEMBL4738555 | 0.75 | ADAM17 (0.39) | ADAM17 | |
| SCHEMBL4735173 | 0.74 | CA2 (0.33) | ADAM17MMP8MMP14MAOB | |
| SCHEMBL4736892 | 0.74 | CA2 (0.32) | — | |
| SCHEMBL5067169 | 0.74 | MMP8 (0.33) | ADAM17MMP8MMP14MAOB | |
| SCHEMBL4736774 | 0.74 | MEN1 (0.31) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076046-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |