Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738921 | 0.83 | TRPM8 (0.43) | CACNA1HPDK1MAPK14 | |
| SCHEMBL4735397 | 0.79 | ALDH1A1 (0.43) | ALDH1A1NPC1RAB9ARAD52GAA | |
| SCHEMBL4733787 | 0.79 | KMT2A (0.48) | ALDH1A1NPC1RAB9AGAAMAPT | |
| SCHEMBL4736030 | 0.78 | CACNA1H (0.47) | ALDH1A1CYP3A4CACNA1HKDM4EMAPK14 | |
| SCHEMBL3071006 | 0.78 | CACNA1H (0.47) | ALDH1A1RAB9AMAPTCYP3A4LMNA | |
| SCHEMBL4734213 | 0.77 | LMNA (0.54) | ALDH1A1NPC1RAB9AGAAMAPT | |
| SCHEMBL4733659 | 0.77 | CACNA1H (0.41) | CACNA1HPDK1MAPK14LTB4R2 | |
| SCHEMBL3821700 | 0.76 | CNR2 (0.49) | GAACACNA1HPDK1MAPK14LTB4R2 | |
| SCHEMBL4736795 | 0.76 | CACNA1H (0.43) | NPC1RAB9AMAPTLMNACACNA1H | |
| SCHEMBL3064331 | 0.75 | CACNA1H (0.45) | CYP3A4CACNA1HPOLBSMN1; SMN2LTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |