Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | PKLR | P30613 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732335 | 0.85 | SFRP1 (0.44) | SFRP1KMT2AMEN1HTTPSEN1 | |
| SCHEMBL4732377 | 0.84 | WNT3 (0.34) | SFRP1KMT2AMEN1HTTPSEN1 | |
| SCHEMBL4734739 | 0.82 | SFRP1 (0.43) | SFRP1POLBEPHX2PKLRMAPT | |
| SCHEMBL4734889 | 0.81 | SFRP1 (0.47) | SFRP1HTTPKMEPHX2PKLR | |
| SCHEMBL4730886 | 0.79 | MEN1 (0.36) | SFRP1KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL4734135 | 0.79 | SFRP1 (0.50) | SFRP1KMT2AMEN1POLBPKM | |
| SCHEMBL4730135 | 0.78 | PKM (0.39) | KMT2AMEN1HTTPOLBPKM | |
| SCHEMBL4730501 | 0.74 | DPP4 (0.39) | SFRP1POLBEPHX2ALDH1A1 | |
| SCHEMBL4730880 | 0.73 | MEN1 (0.36) | SFRP1KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL4734751 | 0.73 | SFRP1 (0.50) | SFRP1KMT2AMEN1POLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |