Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 9/20 | 0.43 |
| ▸ | WNT3 | P56703 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKLR | P30613 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734889 | 0.92 | SFRP1 (0.47) | SFRP1PKLREPHX2CYP3A4LMNA | |
| SCHEMBL4732377 | 0.82 | WNT3 (0.34) | SFRP1WNT3GAAEPHX2CYP3A4 | |
| SCHEMBL4734205 | 0.82 | SFRP1 (0.43) | SFRP1POLBPKLREPHX2MAPT | |
| SCHEMBL4730886 | 0.82 | MEN1 (0.36) | SFRP1POLBCYP3A4LMNATP53 | |
| SCHEMBL4734307 | 0.78 | SFRP1 (0.47) | SFRP1PKLREPHX2CYP3A4LMNA | |
| SCHEMBL4730501 | 0.77 | DPP4 (0.39) | SFRP1POLBEPHX2CYP3A4DPP4 | |
| SCHEMBL4801378 | 0.77 | KDM4E (0.39) | SFRP1KDM4EPOLBGAACYP3A4 | |
| SCHEMBL4730880 | 0.76 | MEN1 (0.36) | SFRP1POLBCYP3A4LMNATP53 | |
| SCHEMBL4733498 | 0.73 | EPHX2 (0.40) | SFRP1POLBEPHX2DPP4KCNH2 | |
| SCHEMBL4731040 | 0.72 | SFRP1 (0.42) | SFRP1POLBEPHX2DPP4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |