Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 7/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PKLR | P30613 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734739 | 0.92 | SFRP1 (0.43) | SFRP1EPHX2EPHX1CCR8LMNA | |
| SCHEMBL4734307 | 0.86 | SFRP1 (0.47) | SFRP1L3MBTL1CCNT1RAB9AEPHX2 | |
| SCHEMBL4730886 | 0.81 | MEN1 (0.36) | SFRP1RAB9ACCR8LMNAALDH1A1 | |
| SCHEMBL4734205 | 0.81 | SFRP1 (0.43) | SFRP1EPHX2PKMALDH1A1HTT | |
| SCHEMBL4732377 | 0.79 | WNT3 (0.34) | SFRP1L3MBTL1EPHX2LMNAALDH1A1 | |
| SCHEMBL4730880 | 0.76 | MEN1 (0.36) | SFRP1RAB9ACCR8LMNAALDH1A1 | |
| SCHEMBL4730501 | 0.74 | DPP4 (0.39) | SFRP1L3MBTL1EPHX2CCR8ALDH1A1 | |
| SCHEMBL4734135 | 0.70 | SFRP1 (0.50) | SFRP1L3MBTL1EPHX2LMNAPKM | |
| SCHEMBL4733498 | 0.70 | EPHX2 (0.40) | SFRP1L3MBTL1EPHX2CCR8ALDH1A1 | |
| SCHEMBL4801378 | 0.70 | KDM4E (0.39) | SFRP1L3MBTL1ALDH1A1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |