Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730135 | 0.81 | PKM (0.39) | KDM4EPOLBGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL4734739 | 0.77 | SFRP1 (0.43) | KDM4EPOLBGAACYP3A4SFRP1 | |
| SCHEMBL4734889 | 0.70 | SFRP1 (0.47) | CYP3A4SFRP1L3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL4734556 | 0.62 | KCNK2 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4818827 | 0.62 | PSEN1 (0.73) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8364179 | 0.62 | LMNA (0.45) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4395827 | 0.60 | CACNA1B (0.75) | CYP3A4L3MBTL1NR1I2CACNA1B | |
| SCHEMBL4795055 | 0.59 | KMT2A (0.39) | KDM4EPOLBGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL12761129 | 0.59 | L3MBTL1 (0.75) | POLBGAASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL4733330 | 0.59 | ALDH1A1 (0.36) | GAAPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |